SARS-CoV-2 infection, resulting in Coronavirus disease 2019 (COVID-19), has significantly affected the entire world. It was labelled a pandemic by World Health Organization. Although it commonly produces respiratory symptoms, neurological features have been described. Neurological manifestations may vary from non-specific symptoms such as headache, dizziness, myalgia and/or fatigue, olfactory or taste dysfunction to specific syndromes including meningitis, stroke, acute transverse myelitis and Guillain-Barre syndrome. This review describes potential pathogenetic mechanisms and neurological manifestations of COVID-19 along with its management. Considering structural and pathogenetic similarity of SARS-CoV-2 with SARS-CoV and MERS viruses, we compared their neurological manifestations and mentioned few features expected in COVID-19 in future. Interestingly, many COVID-19 cases may present with pure neurological manifestations at onset with non-neurological features manifesting few days later and we propose the term “Neuro-COVID syndrome” for such cases. Awareness of neurological manifestations may facilitate its management and improve outcome in such patients.

SARS-CoV-2 感染导致 2019 年冠状病毒病 (COVID-19)，对全世界产生了重大影响。世界卫生组织将其标记为大流行病。尽管它通常会产生呼吸道症状，但已描述了神经系统特征。神经系统表现可能多种多样，从非特异性症状（如头痛、头晕、肌痛和/或疲劳、嗅觉或味觉功能障碍）到特定综合征（包括脑膜炎、中风、急性横贯性脊髓炎和格林-巴利综合征）。这篇综述描述了 COVID-19 的潜在发病机制和神经系统表现及其治疗。考虑到 SARS-CoV-2 与 SARS-CoV 和 MERS 病毒的结构和致病相似性，我们比较了它们的神经学表现，并提到了未来 COVID-19 中预期的一些特征。有趣的是，许多 COVID-19 病例在发病时可能表现出纯粹的神经系统表现，几天后才出现非神经系统特征，我们建议将此类病例称为“神经 COVID 综合征”。对神经系统表现的认识可能有助于其管理并改善此类患者的预后。