Molecularly imprinted polymers (MIP) are known as high selective sorbent, however, its application in aqueous medium is very limiting. In this way, a new hybrid MIP was successfully synthesized for saccharin (SAC) extraction in aqueous medium. SAC determination in surface waters becomes a challenge due to high dissipation that results in low concentration and susceptibility to potential interferences. Two polymer materials synthesized through bulk (HMIP-B) and suspension (HMIP-S) polymerizations were studied, and its performance has been compared according to morphological, adsorption isotherms, thermodynamics, and selectivity properties. The adsorption process was thermodynamically favorable and adsorption capacities (q_e) were 1.24 and 4.32 mg g^-1 for HMIP-B and HMIP-S, respectively. The material was characterized as heterogeneous with two binding sites fitted by Langmuir–Freundlich model and pseudo-second-order model. The imprinting factor (IF) was 4.8 for both materials and the HMIP-S presented superior results in selectivity, with a distribution constant (K_d) value of 12.1 times higher than HMIP-B for saccharin and a selectivity coefficient (k) of 7.73, 9.25 and 2.54 for acesulfame, caffeine and cyclamate, respectively. The selecitivity of HMIP in aqueous medium was tested in surface water samples, resulting in 89% of SAC recovery.

分子印迹聚合物（MIP）被称为高选择性吸附剂，但是，其在水性介质中的应用受到很大限制。通过这种方法，成功合成了一种新的混合MIP，用于在水性介质中提取糖精（SAC）。由于高耗散导致低浓度和对潜在干扰的敏感性，地表水中的SAC测定成为一个挑战。研究了通过本体（HMIP-B）和悬浮（HMIP-S）聚合合成的两种聚合物材料，并根据形态，吸附等温线，热力学和选择性特性比较了其性能。吸附过程在热力学上是有利的，吸附容量（q _e）为1.24和4.32 mg g ^-1分别用于HMIP-B和HMIP-S。该材料具有两种不同的结合位点，分别由Langmuir-Freundlich模型和伪二级模型拟合。两种材料的印迹因子（IF）均为4.8，HMIP-S在选择性方面表现出优异的结果，糖精的分布常数（K _d）值比HMIP-B高12.1倍，选择性系数（k）为7.73分别为乙酰磺胺酸，咖啡因和甜蜜素的9.25和2.54。在地表水样品中测试了HMIP在水性介质中的选择性，可回收89％的SAC。