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The Exposome in the Era of One Health
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2021-01-08 , DOI: 10.1021/acs.est.0c07033
Peng Gao 1
Affiliation  

Current studies on environmental chemistry mainly focus on a single stressor or single group of stressors, which does not reflect the multiple stressors in the dynamic exposome we are facing. Similarly, current studies on environmental toxicology mostly target humans, animals, or the environment separately, which are inadequate to solve the grand challenge of multiple receptors in One Health. Though chemical, biological, and physical stressors all pose health threats, the susceptibilities of different organisms are different. As such, significant relationships and interactions of the chemical, biological, and physical stressors in the environment and their holistic environmental and biological consequences remain unclear. Fortunately, the rapid developments in various techniques, as well as the concepts of multistressors in the exposome and multireceptor in One Health provide the possibilities to understand our environment better. Since the combined stressor is location-specific and mixture toxicity is species-specific, more comprehensive frameworks to guide risk assessment and environmental treatment are urgently needed. Here, three conceptual frameworks to categorize unknown stressors, spatially visualize the riskiest stressors, and investigate the combined effects of multiple stressors across multiple species within the concepts of the exposome and One Health are proposed for the first time.

中文翻译:

一生时代的暴风雨

当前对环境化学的研究主要集中在单个应激源或单个应激源组上,这不能反映我们面临的动态暴露体中的多个应激源。同样,当前有关环境毒理学的研究主要针对人类,动物或环境,这不足以解决《一个健康》中多种受体的巨大挑战。尽管化学,生物和物理应激源都对健康构成威胁,但不同生物的敏感性不同。因此,环境中化学,生物和物理应激源之间的重要关系和相互作用及其整体环境和生物学后果仍然不清楚。幸运的是,各种技术的飞速发展,以及《一个健康》中暴露体中的多应激源和多受体的概念为更好地了解我们的环境提供了可能性。由于组合的应激源是针对特定地点的,而混合毒性是针对特定物种的,因此迫切需要更全面的框架来指导风险评估和环境处理。在此,首次提出了三个概念框架,用于对未知应激源进行分类,在空间上可视化风险最大的应激源,并在暴露体和“一个健康”的概念内研究跨多个物种的多种应激源的组合作用。迫切需要更全面的框架来指导风险评估和环境处理。在此,首次提出了三个概念框架,用于对未知应激源进行分类,在空间上可视化风险最大的应激源,并在暴露体和“一个健康”的概念内研究跨多个物种的多种应激源的组合作用。迫切需要更全面的框架来指导风险评估和环境处理。在此,首次提出了三个概念框架,用于对未知应激源进行分类,在空间上可视化风险最大的应激源,并在暴露体和“一个健康”的概念内研究跨多个物种的多种应激源的组合作用。
更新日期:2021-03-02
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