ABSTRACT

A vast proportion of coronavirus disease 2019 (COVID-19) individuals remain asymptomatic and can shed severe acute respiratory syndrome (SARS-CoV) type 2 virus to transmit the infection, which also explains the exponential increase in the number of COVID-19 cases globally. Furthermore, the rate of recovery from clinical COVID-19 in certain pockets of the globe is surprisingly high. Based on published reports and available literature, here, we speculated a few immunovirological mechanisms as to why a vast majority of individuals remain asymptomatic similar to exotic animal (bats and pangolins) reservoirs that remain refractile to disease development despite carrying a huge load of diverse insidious viral species, and whether such evolutionary advantage would unveil therapeutic strategies against COVID-19 infection in humans. Understanding the unique mechanisms that exotic animal species employ to achieve viral control, as well as inflammatory regulation, appears to hold key clues to the development of therapeutic versatility against COVID-19.

中文翻译：

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无症状 SARS-CoV-2 感染：这一切都是因为对病毒零部件的先天免疫感应不敏感吗？——来自外来动物宿主的线索

 抽象的

很大一部分 2019 冠状病毒病 (COVID-19) 个体仍然无症状，并且可以通过传播严重急性呼吸综合征 (SARS-CoV) 2 型病毒来传播感染，这也解释了全球 COVID-19 病例数量呈指数级增长的原因。此外，全球某些地区的临床 COVID-19 康复率高得惊人。根据已发表的报告和现有文献，我们推测了一些免疫病毒学机制，解释了为什么绝大多数个体仍然没有症状，类似于外来动物（蝙蝠和穿山甲）的宿主，尽管它们携带着大量不同的阴险病毒，但仍然难以疾病的发展。病毒种类，以及这种进化优势是否会揭示针对人类 COVID-19 感染的治疗策略。了解外来动物物种用于实现病毒控制和炎症调节的独特机制，似乎为开发针对 COVID-19 的多功能治疗方法提供了关键线索。