The participation of sirtuins in the regulation of oxidative stress and inflammation lies at the basis of their possible modes of action and is related to their expression in various cell structures; their location in the mitochondria and blood plasma has been indicated as of primary importance. Despite many existing studies, research on sirtuins continues to present an opportunity to discover new functions and dependencies, especially when it comes to women’s gynecological health. Sirtuins have a significant role in both the formation and the course of many gynecological diseases. Their role is particularly important and well documented in the course of the development of cancer within the female reproductive organs; however, disturbances observed in the ovary and oocyte as well as in follicular fluid are also widely investigated. Additionally, sirtuins take part in some gynecological disturbances as regulative factors in pathways associated with insulin resistance, glucose and lipids metabolism disorders. In this review, we would like to summarize the existing knowledge about sirtuins in the manner outlined above.

中文翻译：

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Sirtuins——女性妇科健康新的重要参与者


Sirtuins 参与氧化应激和炎症的调节取决于其可能的作用模式，并与其在各种细胞结构中的表达有关；它们在线粒体和血浆中的位置已被表明是最重要的。尽管已有许多研究，但对去乙酰化酶的研究仍然为发现新功能和依赖性提供了机会，特别是在女性妇科健康方面。 Sirtuins 在许多妇科疾病的形成和病程中发挥着重要作用。它们的作用在女性生殖器官癌症的发展过程中尤其重要并且有据可查；然而，在卵巢和卵母细胞以及卵泡液中观察到的干扰也得到了广泛的研究。此外，sirtuins 作为与胰岛素抵抗、葡萄糖和脂质代谢紊乱相关途径的调节因素，参与了一些妇科疾病。在这篇综述中，我们想以上述方式总结有关 Sirtuins 的现有知识。