BACKGROUND Postprandial hyperglycemia and decreased insulin secretion are relevant to risk factors in the development of type 2 diabetes and its complications. Plant foods with antidiabetic properties could be an affordable alternative in the prevention and treatment of this disease. In the present study, the antihyperglycemic and hypoglycemic activity of Bixa orellana, Psidum guajava L., Cucurbita moschata, Raphanus sativus L. and Brassica oleracea var. capitata, Mayan plant foods, were evaluated at doses of 5 and 10 mg kg-1 . The antihyperglycemic activity was measured in Wistar rats healthy and obese inducted by high sucrose diet (group HSD) (20%). The hypoglycemic activity in healthy CD1 mice. RESULTS Fasting glucose, Lee's index, and the body weight of HSD rats increased significantly (p≤0.05) after 12 weeks of induction compared to the healthy rats. In healthy rats, P. guajava and B. orellana (10 mg kg-1 ) demonstrated higher and statistically different (p≤0.05) antihyperglycemic activity than control acarbose (0.5 mg kg-1 ). The antihyperglycemic activity in the HSD rat group, all Mayan plant foods (10 mg kg-1 ) were statistically equal (p≤0.05) to acarbose. However, B. oleracea and R. sativus registered the highest antihyperglycemic activity. B. orellana and P. guajava (5 mg kg-1 ) showed similar hypoglycemic activity (p≤0.05) to glibenclamide (0.5 mg kg-1 ) but did not significant (p≤0.05) compared to insulin (5 UI kg-1 ). CONCLUSION The present study provides valuable evidence on the possible health benefits of Mayan plant foods. These foods could contribute to the development of therapeutic diet strategies for the prevention and treatment of diabetes. This article is protected by copyright. All rights reserved.

中文翻译：

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“玛雅植物性食物在啮齿动物模型中的抗高血糖和低血糖活性”

背景 餐后高血糖和胰岛素分泌减少与 2 型糖尿病及其并发症发展中的危险因素有关。具有抗糖尿病特性的植物性食品可能是预防和治疗这种疾病的一种负担得起的替代品。在本研究中，Bixa orellana、Psidum guajava L.、Cucurbita moschata、Raphanus sativus L. 和 Brassica oleracea var. 的抗高血糖和降血糖活性。以 5 和 10 mg kg-1 的剂量评估了玛雅植物食品卡塔塔。在高蔗糖饮食（HSD 组）（20%）诱导的健康和肥胖 Wistar 大鼠中测量抗高血糖活性。健康 CD1 小鼠的降血糖活性。结果HSD大鼠的空腹血糖、Lee指数和体重显着升高（p≤0. 05) 诱导 12 周后与健康大鼠相比。在健康大鼠中，P. guajava 和 B. orellana (10 mg kg-1 ) 表现出比对照阿卡波糖 (0.5 mg kg-1 ) 更高且具有统计学差异 (p≤0.05) 的抗高血糖活性。HSD 大鼠组中的抗高血糖活性，所有玛雅植物性食物（10 mg kg-1 ）在统计学上与阿卡波糖相等（p≤0.05）。然而，B. oleracea 和 R. sativus 的抗高血糖活性最高。B. orellana 和 P. guajava (5 mg kg-1 ) 显示出与格列本脲 (0.5 mg kg-1 ) 相似的降血糖活性 (p≤0.05) 但与胰岛素 (5 UI kg-1 ) 相比没有显着性 (p≤0.05) ）。结论 本研究为玛雅植物性食物可能对健康带来的益处提供了宝贵的证据。这些食物可能有助于制定预防和治疗糖尿病的治疗性饮食策略。本文受版权保护。版权所有。