Autoimmune disorders currently affect 5%‐8% of the global population, characterized by an aberrant chronic inflammatory response to self‐antigens. The aim of this study was to systematically review the current available evidence investigating the impact of systemic autoimmune diseases and associated immunosuppressive treatment on fertility parameters of adult men. Clinical trials, observational studies, and case reports written in English and reporting semen analysis, evaluation of seminal oxidative stress, and/or sperm DNA fragmentation in patients affected by psoriasis and psoriatic arthritis, celiac disease, inflammatory bowel diseases, systemic lupus erythematosus, ankylosing spondylitis, hidradenitis suppurativa, uveitis, dermatomyositis, and rheumatoid arthritis were collected by searching on PubMed, EMBASE, OVID, Scopus, and Cochrane Library databases, with no limit of time. The study quality and the extent of bias in design, methods, and outcome assessment were evaluated by applying the Joanna Briggs Institute Critical Appraisal tools. Evidence suggested that various autoimmune diseases or relevant medications can adversely affect male fertility parameters and that patients may benefit of counseling and sperm cryopreservation. Clinical trials further investigating any adverse effect of autoimmunity and related thereby on male infertility are warranted, to develop appropriate guidelines for males diagnosed and treated for autoimmune disorders.

中文翻译：

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自身免疫性全身炎症和相关药物对慢性风湿病、皮肤病和胃肠病患者男性生殖健康的影响：系统评价

自身免疫性疾病目前影响全球 5%-8% 的人口，其特征是对自身抗原的异常慢性炎症反应。本研究的目的是系统地回顾目前调查全身性自身免疫性疾病和相关免疫抑制治疗对成年男性生育参数影响的现有证据。以英文撰写的临床试验、观察性研究和病例报告，并报告受银屑病和银屑病关节炎、乳糜泻、炎症性肠病、系统性红斑狼疮、强直性脊柱炎患者影响的精液分析、精液氧化应激评估和/或精子 DNA 断裂通过在 PubMed、EMBASE、OVID、Scopus、和 Cochrane 图书馆数据库，没有时间限制。通过应用乔安娜布里格斯研究所批判性评估工具评估研究质量和设计、方法和结果评估的偏倚程度。有证据表明，各种自身免疫性疾病或相关药物会对男性生育参数产生不利影响，患者可能会受益于咨询和精子冷冻保存。需要进一步研究自身免疫的任何不利影响及其对男性不育的相关影响的临床试验，以便为诊断和治疗自身免疫性疾病的男性制定适当的指南。有证据表明，各种自身免疫性疾病或相关药物会对男性生育参数产生不利影响，患者可能会受益于咨询和精子冷冻保存。需要进一步研究自身免疫的任何不利影响及其对男性不育的相关影响的临床试验，以便为诊断和治疗自身免疫性疾病的男性制定适当的指南。有证据表明，各种自身免疫性疾病或相关药物会对男性生育参数产生不利影响，患者可能会受益于咨询和精子冷冻保存。需要进一步研究自身免疫的任何不利影响及其对男性不育的相关影响的临床试验，以便为诊断和治疗自身免疫性疾病的男性制定适当的指南。