Contaminants of emerging concern (CECs) are one of the main barriers in the water cycle as they limit the water reuse due to their adverse effects on humans and the ecosystem. Natural and/or engineered ecosystems, such as conventional wastewater treatment processes, are not designed to remove CECs and contribute to the bioaccumulation in organisms considering high volumes of treated water discharges. The adoption of innovative solutions to upgrade urban water cycle facilities has gained relevance for the removal of these substances from final effluents. Molecularly imprinted polymers (MIPs) show promising selective removal toward a wide range of CECs. However, this solution is still limited to lab/bench scale and needs to be critically analyzed and assessed for possible scale-up in real environment. Therefore, in this review, an overview of the fate and occurrence of CECs in wastewater is initially reported together with the state-of-the-art in adsorption mechanisms to remove these compounds. In the central part of the paper, an evaluation of MIPs synthesis and their status in removing CECs from water matrix are presented. An upscaling pathway of MIPs column from lab- to pilot-scale is given to be applied for enhanced CECs removal and safe water reuse in irrigation/fertigation. Finally, possible integrations of MIP columns to real wastewater treatment facilities is discussed and advantages and disadvantages of the potential solutions are addressed to enhance their sustainability.

受到关注的污染物（CEC）是水循环中的主要障碍之一，因为它们对人类和生态系统产生不利影响，因此限制了水的再利用。天然和/或工程生态系统，例如常规废水处理工艺，并非旨在消除CEC，并考虑到大量处理后的废水排放而导致生物体内的生物蓄积。采用创新的解决方案来升级城市水循环设施，对于从最终废水中去除这些物质具有重要意义。分子印迹聚合物（MIP）对多种CEC均显示出有希望的选择性去除。但是，该解决方案仍然仅限于实验室/工作台规模，需要对其进行严格的分析和评估，以在实际环境中进行可能的扩展。因此，在这篇评论中，最初报道了废水中CEC的命运和发生情况的概述，以及有关去除这些化合物的最新吸附机理。在本文的中心部分，对MIP的合成及其在从水基质中去除CEC的地位进行了评估。MIPs色谱柱从实验室规模扩大到中试规模的途径被应用于增强CEC去除能力和灌溉/施肥中的安全水再利用。最后，讨论了将MIP色谱柱与实际废水处理设施集成的可能性，并探讨了潜在解决方案的优缺点，以增强其可持续性。介绍了MIPs合成的评估及其在从水基质中去除CEC方面的地位。MIPs色谱柱从实验室规模扩大到中试规模的途径被应用于增强CEC去除能力和灌溉/施肥中的安全水再利用。最后，讨论了将MIP色谱柱与实际废水处理设施集成的可能性，并探讨了潜在解决方案的优缺点，以增强其可持续性。介绍了MIPs合成的评估及其在从水基质中去除CEC方面的地位。MIPs色谱柱从实验室规模扩大到中试规模的途径被应用于增强CEC去除能力和灌溉/施肥中的安全水再利用。最后，讨论了将MIP色谱柱与实际废水处理设施集成的可能性，并探讨了潜在解决方案的优缺点，以增强其可持续性。