Human functional brain networks can be reliably characterized within individuals using precision functional mapping. This approach entails the collection of large quantities of functional magnetic resonance imaging (fMRI) data from each individual subject. Studies employing precision functional mapping in the cerebral cortex have found that individuals manifest unique representations of functional brain networks around a central tendency described by previous group average approaches. We recently extended precision functional mapping to the subcortex and cerebellum, which has revealed several novel organizational principles within these structures. Here, we detail these principles and provide insights into how precision functional mapping of subcortical structures and the cerebellum may become clinically translatable.

使用精确的功能映射可以可靠地表征个体的人类功能性大脑网络。这种方法需要从每个受试者收集大量功能磁共振成像 (fMRI) 数据。在大脑皮层中采用精确功能映射的研究发现，个体围绕先前群体平均方法描述的集中趋势表现出功能性大脑网络的独特表征。我们最近将精确的功能映射扩展到皮层下和小脑，这揭示了这些结构中的一些新颖的组织原则。在这里，我们详细介绍了这些原理，并深入探讨了皮层下结构和小脑的精确功能映射如何可以临床转化。