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The simple and “green” synthesis of highly substituted furan derivatives containing rare 5-amino-3-aroylfuran moiety
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2021-01-09 , DOI: 10.1016/j.tetlet.2020.152798
Sergey Karpov , Yakov Kayukov , Arthur Grigor'ev , Oleg Nasakin , Olga Kayukova , Viktor Tafeenko

The reaction of potassium 2-aroyl-1,3-dicyano-1,3-bis-methoxycarbonylpropenides with hydrogen peroxide is unusual for compounds of this type and results in formation of highly substituted 5-amino-3-aroylfuran derivatives. In contrast to few related literature methods leading to formation of this moiety, the advantages of this synthesis includes a readily available and inexpensive precursors, non-usage of any toxic reagents or solvents and short process time. The structure of one of the obtained compounds was determined by X-ray diffraction.



中文翻译:

含有稀有的5-氨基-3-芳酰基呋喃部分的高度取代的呋喃衍生物的简单“绿色”合成

2-芳酰基-1,3-二氰基-1,3--甲氧基羰基丙烯腈的钾与过氧化氢的反应对于这种类型的化合物是不寻常的,并且导致形成高度取代的5-氨基-3-芳酰基呋喃衍生物。与很少的导致形成该部分的相关文献方法相反,这种合成的优点包括容易获得且便宜的前体,不使用任何有毒试剂或溶剂以及处理时间短。通过X射线衍射确定所获得的化合物之一的结构。

更新日期:2021-02-04
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