Factor XII (FXII) deficiency is a rare genetic blood disorder. It can lead to a higher risk of developing deep vein thrombosis or acquired thrombotic disorders than the general population. This retrospective study evaluated patients who opted for surgery and were found to have abnormal clotting profiles and clotting factors on preoperative routine blood. Patients were included regardless of whether they were symptomatic or asymptomatic. The cohort comprised 115 patients with a mean FXII level of 128.04 ± 36.93%. Two (1.79%) patients, both of whom were women, had FXII levels <60%. The mean FXII level was 58 ± 1.41 (range, 57–59%) in this group. The present study shows the prevalence of FXII in the asymptomatic Saudi population. The results provide the normal range for FXII. The findings of our study provide the basis for diagnosing F XII deficiency in the asymptomatic Saudi population.

XII因子（FXII）缺乏症是一种罕见的遗传性血液病。与一般人群相比，它可能导致发生深静脉血栓形成或获得性血栓形成障碍的风险更高。这项回顾性研究评估了选择手术并且发现术前常规血液中凝血特征和凝血因子异常的患者。无论患者是有症状的还是无症状的，都包括在内。该队列包括115名患者，平均FXII水平为128.04±36.93％。两名（1.79％）患者（均为女性）的FXII水平低于60％。该组的平均FXII水平为58±1.41（范围为57–59％）。本研究表明FXII在无症状沙特人群中的流行。结果提供了FXII的正常范围。我们的研究结果为诊断提供依据无症状的沙特阿拉伯人群中的F XII缺乏症。