Marek's disease virus (MDV), the causative agent of Marek's disease (MD), results in highly infectious phymatosis, lymphatic tissue hyperplasia, and neoplasia. MD is associated with high morbidity and mortality rate. Non-coding RNAs (ncRNAs) entails long non-coding RNA (lncRNA) and microRNA (miRNA). Numerous studies have reported that specific miRNAs and lncRNAs participate in multiple cellular processes, such as proliferation, migration, and tumor cell invasion. Specialized miRNAs and lncRNAs militate a similar role in MD tumor oncogenesis. Despite its growing popularity, only a few reviews are available on ncRNA in MDV tumor oncogenes. Herein, we summarized the role of the miRNAs and lncRNAs in MD tumorigenesis. Altogether, we brought forth the research issues, such as MD prevention, screening, regulatory network formation, novel miRNAs, and lncRNAs analysis in MD that needs to be explored further. This review provides a theoretical platform for the further analysis of miRNAs and lncRNAs functions and the prevention and control of MD and malignancies in domestic animals.

马立克氏病病毒（MD）是马立克氏病（MD）的病原体，可导致高度传染性的气肿，淋巴组织增生和瘤形成。MD与高发病率和高死亡率有关。非编码RNA（ncRNA）需要较长的非编码RNA（lncRNA）和microRNA（miRNA）。大量研究报告说，特定的miRNA和lncRNA参与多种细胞过程，例如增殖，迁移和肿瘤细胞侵袭。专门的miRNA和lncRNA在MD肿瘤的发生中具有类似的作用。尽管它越来越受欢迎，但是关于MDV肿瘤癌基因中ncRNA的评论很少。本文中，我们总结了miRNA和lncRNA在MD肿瘤发生中的作用。我们总共提出了研究问题，例如MD预防，筛查，调控网络形成，新型miRNA，MD中的lncRNA分析，还有待进一步探讨。这篇综述为进一步分析miRNA和lncRNAs的功能以及预防和控制家畜中的MD和恶性肿瘤提供了理论平台。