Ceftazidime (CF) is an antibiotic, used in treatment of many serious bacterial infections. Determination of this antibiotic is essential because of its dangerous side effects. This work introduces a novel sensitive optical nanosensor based on carbon dots (CDs) synthesized using citric acid through bottom-up method, embedded in silica molecularly imprinted polymer (SMIP). This probe was made by embedding CDs as fluorophore materials, and ceftazidime as a template molecule in SMIP then washing the template molecules to provide CDs embedded in SMIP (CDs-SMIP). The synthesized materials were characterized by UV–vis (UV/Vis), fluorescence spectrophotometry, Fourier transform infrared spectrometry (FTIR), Transmission electron microscopy (TEM), and Scanning electron microscope (SEM). The obtained CD-SMIP showed strong fluorescence emission with a symmetric peak at 420 nm using excitation at 340 nm. This synthesized probe was finally applied for the detection of ceftazidime. The fluorescence intensity of CDs-SMIP quenched in presence of ceftazidime molecules. The designed fluorescence probe responded to concentration of ceftazidime over a linear range of 0.18−1.27 μg.L⁻¹ (0.33–2.32 nmol.L⁻¹), also, the limit of detection (LOD) and the relative standard deviation (RSD) were 0.06 μg.L⁻¹ (0.11 nmol.L⁻¹) and 3.20% (n = 5), respectively. The introduced chemical nanosensor was used to analyze ceftazidime in urine samples satisfactory.

头孢他啶（CF）是一种抗生素，用于治疗许多严重的细菌感染。由于这种抗生素具有危险的副作用，因此必须对其进行测定。这项工作介绍了一种新型的基于碳点（CD）的灵敏光学纳米传感器，该碳点通过柠檬酸通过自下而上的方法合成，并嵌入二氧化硅分子印迹聚合物（SMIP）中。通过将CD嵌入为荧光团材料，将头孢他啶作为模板分子嵌入SMIP，然后洗涤模板分子以提供嵌入SMIP的CD（CDs-SMIP），制成该探针。合成的材料通过紫外可见（UV / Vis），荧光分光光度法，傅里叶变换红外光谱（FTIR），透射电子显微镜（TEM）和扫描电子显微镜（SEM）进行表征。使用340nm的激发，获得的CD-SMIP显示强荧光发射，并在420nm具有对称峰。最终将该合成探针用于头孢他啶的检测。CDs-SMIP的荧光强度在头孢他啶分子的存在下淬灭。设计的荧光探针在0.18-1.27μg.L的线性范围内对头孢他啶的浓度有响应^-1（0.33-2.32 nmol.L ^-1），检测限（LOD）和相对标准偏差（RSD）分别为0.06μg.L ^{- 1}（0.11 nmol.L ^-1）和3.20％（n = 5）。引入的化学纳米传感器用于分析令人满意的尿液样品中的头孢他啶。