Curiosity and intent to use alcohol in pre-adolescence is a risk factor for later experimentation and use, yet we know little of how curiosity about use develops. Here, we examine factors that may influence curiosity about alcohol use, as it may be an important predictor of later drinking behavior. Cross-sectional data on youth ages 10–11 from the ongoing Adolescent Brain Cognitive Development℠ (ABCD) Study Year 1 follow-up were used (n = 2,334; NDA 2.0.1). All participants were substance-naïve at time of assessment. Group factor analysis identified latent factors across common indicators of risk for early substance use (i.e., psychopathology and trait characteristics; substance use attitudes/behaviors; neurocognition; family and environment). Logistic mixed-effect models tested associations between latent factors of risk for early substance use and curiosity about alcohol use, controlling for demographics and study site. Two multidimensional factors were significantly inversely and positively associated with greater curiosity about alcohol use, respectively: 1) low internalizing and externalizing symptomatology coupled with low impulsivity, perceived neighborhood safety, negative parental history of alcohol use problems, and fewer adverse life experiences and family conflict; and 2) low perceived risk of alcohol use coupled with lack of peer disapproval of use. When assessing all risk factors in an overall regression, lack of perceived harm from trying alcohol once or twice was associated with greater likelihood of alcohol curiosity. Taken together, perceptions that alcohol use causes little harm and having peers with similar beliefs is related to curiosity about alcohol use among substance-naïve 10–11-year-olds. General mental health and environmental risk factors similarly increase the odds of curiosity for alcohol. Identification of multidimensional risk factors for early alcohol use may point to novel prevention and early intervention targets. Future longitudinal investigations in the ABCD cohort will determine the extent to which these factors and curiosity predict alcohol use among youth.

青春期前对饮酒的好奇心和意图是以后尝试和使用酒精的一个风险因素，但我们对使用酒精的好奇心是如何发展的知之甚少。在这里，我们研究了可能影响对饮酒好奇心的因素，因为它可能是以后饮酒行为的重要预测因素。使用正在进行的青少年大脑认知发展℠ (ABCD) 研究第 1 年随访中 10-11 岁青少年的横断面数据（n = 2,334；NDA 2.0.1）。所有参与者在评估时均未接触过任何物质。群体因素分析确定了早期药物使用风险常见指标的潜在因素（即精神病理学和特质特征；药物使用态度/行为；神经认知；家庭和环境）。逻辑混合效应模型测试了早期物质使用的潜在风险因素与对饮酒的好奇心之间的关联，并控制了人口统计数据和研究地点。两个多维因素分别与对饮酒的好奇心呈显着负相关和正相关：1）内化和外化症状较低，加上较低的冲动性、邻里安全感、父母酗酒问题的不良史以及较少的不良生活经历和家庭冲突; 2) 饮酒的感知风险较低，且同伴不反对饮酒。当评估总体回归中的所有风险因素时，尝试饮酒一次或两次而没有感觉到危害与对酒精好奇的可能性更大有关。总而言之，对于酒精使用造成的危害很小以及有类似信念的同龄人的看法与未接触过药物的 10-11 岁儿童对酒精使用的好奇心有关。 一般心理健康和环境风险因素同样会增加对酒精产生好奇的可能性。识别早期饮酒的多维危险因素可能会指明新的预防和早期干预目标。未来对 ABCD 队列的纵向调查将确定这些因素和好奇心在多大程度上预测青少年饮酒情况。