Stem Cell Reviews and Reports ( IF 4.5 ) Pub Date : 2021-01-08 , DOI: 10.1007/s12015-020-10086-7 Lacy E Lowry 1, 2 , Maryanne C Herzig 2 , Barbara A Christy 2, 3 , Richard Schäfer 4 , Shibani Pati 5 , Andrew P Cap 2, 6 , James A Bynum 2, 7, 8
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Traumatic injuries are a leading cause of death and disability in both military and civilian populations. Given the complexity and diversity of traumatic injuries, novel and individualized treatment strategies are required to optimize outcomes. Cellular therapies have potential benefit for the treatment of acute or chronic injuries, and various cell-based pharmaceuticals are currently being tested in preclinical studies or in clinical trials. Cellular therapeutics may have the ability to complement existing therapies, especially in restoring organ function lost due to tissue disruption, prolonged hypoxia or inflammatory damage. In this article we highlight the current status and discuss future directions of cellular therapies for the treatment of traumatic injury. Both published research and ongoing clinical trials are discussed here.
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中文翻译：
不再被忽视：外伤中新兴的细胞疗法
外伤是军人和平民死亡和残疾的主要原因。鉴于外伤的复杂性和多样性，需要新颖和个性化的治疗策略来优化结果。细胞疗法对治疗急性或慢性损伤具有潜在益处，目前正在临床前研究或临床试验中测试各种基于细胞的药物。细胞疗法可能具有补充现有疗法的能力，特别是在恢复因组织破坏、长期缺氧或炎症损伤而丧失的器官功能方面。在本文中，我们重点介绍了细胞疗法治疗外伤的现状并讨论了未来的发展方向。此处讨论已发表的研究和正在进行的临床试验。
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