Selenium is a trace element necessary for the growth of organisms. Moreover, selenium supplementation can improve the immunity and fertility of the body, as well as its ability to resist oxidation, tumors, heavy metals, and pathogenic microorganisms. However, owing to the duality of selenium, excessive selenium supplementation can cause certain toxic effects on the growth and development of the body and may even result in death in severe cases. At present, increasing attention is being paid to the development and utilization of selenium as a micronutrient, but its potential toxicity tends to be neglected. This study systematically reviews recent research on the toxicological effects of selenium, aiming to provide theoretical references for selenium toxicology-related research and theoretical support for the development of selenium-containing drugs, selenium-enriched dietary supplements, and selenium-enriched foods.

硒是生物体生长所必需的微量元素。而且，补硒可以提高机体的免疫力和生育能力，以及抗氧化、抗肿瘤、抗重金属、抗病原微生物的能力。但由于硒的双重性，过量补充硒会对机体的生长发育产生一定的毒性作用，严重者甚至可能导致死亡。目前，硒作为微量营养素的开发利用越来越受到重视，但其潜在毒性往往被忽视。本研究系统回顾了近年来关于硒毒理学作用的研究，旨在为硒毒理学相关研究提供理论参考，为含硒药物的开发提供理论支持。