Impact of IL-10 Promoter Polymorphisms and IL-10 Serum Levels on Advanced Laryngeal Squamous Cell Carcinoma and Survival Rate.,Cancer Genomics & Proteomics

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Impact of IL-10 Promoter Polymorphisms and IL-10 Serum Levels on Advanced Laryngeal Squamous Cell Carcinoma and Survival Rate.
Cancer Genomics & Proteomics ( IF 2.6 ) Pub Date : 2021-1-10 , DOI: 10.21873/cgp.20241
Agne Pasvenskaite ₁ , Rasa Liutkeviciene ₂ , Greta Gedvilaite ₂ , Alvita Vilkeviciute ₂ , Vykintas Liutkevicius ₃ , Virgilijus Uloza ₃

Affiliation

Prognosis of advanced stages of laryngeal squamous cell carcinoma (LSCC) remains poor. To clarify therapeutic targets and improve survival rate, identification of new specific and prognostic biomarkers of LSCC is required. The study aimed to evaluate the impact of IL-10:rs1800871, rs1800872, rs1800896 single nucleotide polymorphisms (SNPs), and IL-10 serum levels on LSCC development and determine associations of selected SNPs with patient survival rate.

中文翻译：

IL-10 启动子多态性和 IL-10 血清水平对晚期喉鳞状细胞癌和存活率的影响。

喉鳞状细胞癌 (LSCC) 晚期的预后仍然很差。为了明确治疗目标并提高存活率，需要鉴定新的 LSCC 特异性和预后生物标志物。该研究旨在评估 IL-10:rs1800871、rs1800872、rs1800896 单核苷酸多态性 (SNP) 和 IL-10 血清水平对 LSCC 发展的影响，并确定所选 SNP 与患者存活率的关联。

更新日期：2021-01-11

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