In recent years, considerable achievements have been made to motivate the construction of tumor microenvironment (TME)-specific functional nanomaterials, which can effectively respond to the inherent pathological and physicochemical conditions in diseased regions to improve the specificity of imaging and drug delivery. Until now, various nanoarchitectures have been designed to combat cancer effectively and specifically. This review summarizes the latest developments in TME-specific theranostic nanoplatforms based on multifunctional nanomaterials that hold potential for achieving the targeted recognition at tumor sites. Recent progress and achievements have also been summarized for nanosystems that can specifically respond to the TME with various stimulus-responsive strategies and their applications for drug delivery, diagnosis, treatment, and synergistic theranostics of cancer. This review emphasizes the significance of functional nanomaterials in response to tumor stimuli to enhance anticancer treatment efficiency and facilitate development in extensive research fields, including nanoscience, biomedicine, and clinical applications.

中文翻译：

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用于生物医学应用的肿瘤微环境特定功能纳米材料。

近年来，在推动肿瘤微环境（TME）特异性功能纳米材料的构建方面取得了可观的成就，这种材料可以有效地应对患病区域的固有病理和理化状况，从而提高成像和药物递送的特异性。迄今为止，已经设计了各种纳米结构来有效和专门地对抗癌症。这篇综述总结了基于多功能纳米材料的TME特定治疗药物纳米平台的最新发展，该平台具有在肿瘤部位实现靶向识别的潜力。纳米系统的最新进展和成就也得到了总结，这些纳米系统可以通过各种刺激响应策略对TME产生特异性反应，并将其应用于药物递送，诊断，治疗，和癌症的协同治疗学。这篇综述强调了功能性纳米材料对肿瘤刺激的反应的重要性，以增强抗癌治疗效率并促进广泛研究领域的发展，包括纳米科学，生物医学和临床应用。