Metal-organic frameworks (MOFs) are promising new nanocarriers with potential use in anticancer drug delivery. However, there is a scarcity of studies on the uptake and release of guest molecules associated with MOF nanovehicles, and their mechanism is poorly understood. In this work, newly developed iron-based MOFs, namely Fe-NDC nanorods, were investigated as potential nanocarriers for calcein (as a model drug/dye) and Doxorubicin (a chemotherapeutic drug (DOX)). Calcein was successfully loaded by equilibrating its solution with the MOFs nanoparticles under constant stirring. The calcein average encapsulation efficiency achieved was 43.13%, with a corresponding capacity of 17.74 wt.%. In-vitro calcein release was then carried out at 37°C in phosphate buffer saline (PBS) using ultrasound (US) as an external trigger. MOFs released an average of 17.8% (without US), whereas they released up to 95.2% of their contents when 40-kHz US at ~1 W/cm² was applied for 10 min. The Cytotoxic drug DOX was also encapsulated in Fe-NDC, and its In-vitro release profile was determined under the same conditions. DOX encapsulation efficiency and capacity were found to be 16.10% and 13.37 wt.%, respectively. In-vitro release experiments demonstrated significant release, reaching 80% in 245 minutes, under acoustic irradiation, compared to around 6% in the absence of US. Additionally, experimental results showed that Fe-NDC nanoparticles are biocompatible even at relatively high concentrations, with an MCF-7 IC₅₀ of 1022 g/ml. Our work provides a promising platform for anticancer drug delivery by utilizing biocompatible Fe-NDC nanoparticles and US as an external trigger mechanism.

中文翻译：

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从铁基金属有机框架中轻松触发超声触发钙黄绿素和阿霉素的释放。

金属有机框架（MOF）是有前途的新型纳米载体，具有潜在的抗癌药物递送用途。然而，关于与MOF纳米车辆相关的客体分子的摄取和释放的研究很少，其机理尚不清楚。在这项工作中，研究了新开发的铁基MOF，即Fe-NDC纳米棒，作为钙黄绿素（作为模型药物/染料）和阿霉素（化学治疗药物（DOX））的潜在纳米载体。通过在不断搅拌下用MOFs纳米颗粒平衡其溶液来成功加载钙黄绿素。钙黄绿素的平均包封效率为43.13％，相应的容量为17.74 wt。％。然后在37°C的磷酸盐缓冲液（PBS）中使用超声（US）作为外部触发剂进行体外钙黄绿素的释放。财政部平均发布了17。8％（不含US），而当以〜1 W /cm²的40 kHz US施加10分钟时，它们释放的含量高达95.2％。细胞毒性药物DOX也被封装在Fe-NDC中，并在相同条件下测定了其体外释放曲线。发现DOX的包封效率和容量分别为16.10％和13.37重量％。体外释放实验表明，在声辐射下，释放显着释放，在245分钟内达到80％，而在没有US的情况下，释放约达到6％。此外，实验结果表明，即使在相对较高的浓度下，Fe-NDC纳米颗粒也具有生物相容性，MCF-7 IC ₅₀为1022 g / ml。我们的工作通过利用生物相容的Fe-NDC纳米颗粒和US作为外部触发机制，为抗癌药物的输送提供了一个有希望的平台。