Background Sildenafil (Viagra) is widely used for the treatment of erectile dysfunction under various etiologies. Unfortunately, chronic administration of sildenafil negatively affects fertility. The aim of the present study is to investigate the improvement role of sesame on the testis alterations caused by long-term administration of sildenafil on albino rats. Results Light microscopically observations showed that overdoses of sildenafil had provoked tubular and interstitial histological alterations. Tubular degeneration and abnormality in the germinal epithelium of the seminiferous tubules included spermatocyte degeneration and arrest of spermatogenesis. Sperm count and motility were negatively affected by sildenafil. These alterations were improved by sesame feeding. Conclusion Sesame intake improve the side effects of prolonged treatment with sildenafil significantly. These results demonstrate the pivotal role of sesame that may improve male infertility.

中文翻译：

---

西地那非长期服用芝麻对成年白化鼠睾丸的影响

背景 西地那非（伟哥）广泛用于治疗各种病因的勃起功能障碍。不幸的是，长期服用西地那非会对生育能力产生负面影响。本研究的目的是探讨芝麻对白化大鼠长期服用西地那非引起的睾丸改变的改善作用。结果 光学显微镜观察表明，过量服用西地那非已引起肾小管和间质组织学改变。生精小管生发上皮的管状变性和异常包括精母细胞变性和精子发生停滞。精子计数和活力受到西地那非的负面影响。这些改变通过芝麻喂养得到改善。结论芝麻摄入可显着改善西地那非长期治疗的副作用。这些结果证明了芝麻在改善男性不育症方面的关键作用。