Rhus coriaria L. (Anacardiaceae), commonly known as sumac, is a commonly used spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, sumac has been used in traditional medicine for the management and treatment of many ailments including hemorrhoids, wound healing, diarrhea, ulcer, and eye inflammation. This plant is rich in various classes of phytochemicals including flavonoids, tannins, polyphenolic compounds, organic acids, and many others. By virtue of its bioactive, Rhus coriaria possesses powerful antioxidant capacities that have ameliorative and therapeutic benefits for many common diseases including cardiovascular disease, diabetes, and cancer. This review describes the phytochemical properties of R. coriaria and then focuses on the potent antioxidant capacities of sumac. We then dissect the cellular and molecular mechanisms of sumac’s action in modulating many pathophysiological instigators. We show how accumulating evidence supports the antibacterial, antinociceptive, antidiabetic, cardioprotective, neuroprotective, and anticancer effects of this plant, especially that toxicity studies show that sumac is very safe to consume by humans and has little toxicity. Taken together, the findings we summarize here support the utilization of this plant as an attractive target for drug discovery.

中文翻译：

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us（Rusus coriaria L.）的药理和抗氧化活性

Rhus coriaria L.（Anacardiaceae），通常称为漆树，是一种常用的香料，调味品和调味剂，尤其是在地中海地区。由于其丰富的有益价值，漆树已在传统医学中用于治疗和治疗多种疾病，包括痔疮，伤口愈合，腹泻，溃疡和眼睛发炎。这种植物富含各种植物化学物质，包括类黄酮，单宁，多酚化合物，有机酸等。凭借其生物活性，Rus coriaria具有强大的抗氧化能力，对许多常见疾病（包括心血管疾病，糖尿病和癌症）具有改善和治疗作用。这篇评论描述了R. coriaria的植物化学特性然后集中于漆树的强抗氧化能力。然后，我们剖析了漆树在调节许多病理生理学启动子中的作用的细胞和分子机制。我们展示了越来越多的证据如何支持这种植物的抗菌，抗伤害，抗糖尿病，心脏保护，神经保护和抗癌作用，尤其是毒性研究表明漆树胶对人类的食用非常安全并且几乎没有毒性。综上所述，我们在此总结的发现支持该植物被用作药物发现的有吸引力的目标。