The purpose of this study is to conduct a comparative analysis of the consumption of antibiotics for systemic use reimbursed by the state in Kazakhstan for 2017–2019 with the Access, Watch, and Reserve classification (AWaRe 2019) of the World Health Organization (WHO). The evaluation of the consumption of antibiotics for systemic use in Kazakhstan for 2017–2019 was carried out using the ATC/DDD methodology in accordance with the WHO AWaRe classification. The study used data on all antibiotics that were centrally purchased by a single purchaser during the study period. To understand how often Access group antibiotics are taken in Kazakhstan, the top-10 most consumed antibiotics were additionally studied. The results of a comparative analysis of the antibiotics for systemic use consumption for 2017–2019 by the Access, Watch, and Reserve groups showed a negative trend of a decrease in the consumption of Access group drugs from 1.17 defined daily dose (DDDs) per 1000 inhabitants per day (DID) (39%) in 2017 to 0.59 DID (30%) in 2019. There is an increase in consumption of Watch group antibiotics from 1.84 DID (61%) in 2017 to 1.37 DID (68%) in 2019, as well as an increase in consumption of Reserve antibiotics from 0.001 DID (0.03%) to 0.4 DID (2.11%). In recent years in Kazakhstan, there has been a decrease in the consumption of Access group antibiotics. In addition, the Watch group antibiotics are widely consumed with a certain upward trend. In 2019, one Reserve antibiotic was included in the top-10 most commonly consumed antibiotics. There is a predominant consumption of parenteral forms of antibiotics for systemic use in the country.

中文翻译：

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基于世卫组织获取，观察和储备分类的哈萨克斯坦2017-2019年抗生素使用评估（AWaRe 2019）

这项研究的目的是通过世界卫生组织（WHO）的使用，监视和储备分类（AWaRe 2019），对哈萨克斯坦国家在2017-2019年间报销的全身使用抗生素消费量进行比较分析。 。根据世卫组织AWaRe分类标准，使用ATC / DDD方法对2017-2019年哈萨克斯坦全身性使用抗生素的消费量进行了评估。该研究使用了在研究期间由单个购买者集中购买的所有抗生素的数据。为了了解在哈萨克斯坦使用Access组抗生素的频率，还对消耗量最大的前10种抗生素进行了研究。Access，Watch，2017-2019年对全身使用抗生素的比较分析结果 储备组和储备组的消极趋势显示，Access组药物的消费量从2017年的每千居民每日1.17定义的每日剂量（DID）（39％）减少到2019年的0.59 DID（30％）的减少趋势。观察组抗生素的消费量从2017年的1.84 DID（61％）增加到2019年的1.37 DID（68％），以及储备抗生素的消费量从0.001 DID（0.03％）增加到0.4 DID（2.11） ％）。近年来，在哈萨克斯坦，Access组抗生素的消费量有所减少。此外，Watch组抗生素被广泛消费，并有一定的上升趋势。在2019年，十大最常用抗生素中包括一种Reserve抗生素。在该国，全身性使用肠胃外形式抗生素的情况比较普遍。