Non-Histone Protein Methylation: Biological Significance and Bioengineering Potential,ACS Chemical Biology

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Non-Histone Protein Methylation: Biological Significance and Bioengineering Potential
ACS Chemical Biology ( IF 3.5 ) Pub Date : 2021-01-07 , DOI: 10.1021/acschembio.0c00771
Roberto Di Blasi _{1,

2} , Oleg Blyuss _{3,

4,

5} , John F Timms ₆ , Daniel Conole ₇ , Francesca Ceroni _{1,

2} , Harry J Whitwell _{5,

8,

9}

Affiliation

Department of Chemical Engineering, Faculty of Engineering, Imperial College London, London, U.K.
Imperial College Centre for Synthetic Biology, Imperial College London, London, U.K.
School of Physics, Astronomy and Mathematics, University of Hertfordshire, Hatfield, U.K.
Department of Paediatrics and Paediatric Infectious Diseases, Sechenov First Moscow State Medical University, Moscow, Russia.
Department of Applied Mathematics, Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
Department of Women's Cancer, EGA Institute for Women's Health, University College London, London, U.K.
Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London, U.K.
National Phenome Centre and Imperial Clinical Phenotyping Centre, Department of Metabolism, Digestion and Reproduction, IRDB Building, Imperial College London, Hammersmith Campus, London, W12 0NN, U.K.
Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Sir Alexander Fleming Building, Imperial College London, Hammersmith Campus, London, SW7 2AZ, U.K.

Protein methylation is a key post-translational modification whose effects on gene expression have been intensively studied over the last two decades. Recently, renewed interest in non-histone protein methylation has gained momentum for its role in regulating important cellular processes and the activity of many proteins, including transcription factors, enzymes, and structural complexes. The extensive and dynamic role that protein methylation plays within the cell also highlights its potential for bioengineering applications. Indeed, while synthetic histone protein methylation has been extensively used to engineer gene expression, engineering of non-histone protein methylation has not been fully explored yet. Here, we report the latest findings, highlighting how non-histone protein methylation is fundamental for certain cellular functions and is implicated in disease, and review recent efforts in the engineering of protein methylation.

中文翻译：

非组蛋白甲基化：生物学意义和生物工程潜力

蛋白质甲基化是一种关键的翻译后修饰，其对基因表达的影响在过去二十年中得到了深入研究。最近，人们对非组蛋白甲基化重新产生了兴趣，因为它在调节重要的细胞过程和许多蛋白质（包括转录因子、酶和结构复合物）的活性中发挥着作用。蛋白质甲基化在细胞内发挥的广泛而动态的作用也凸显了其生物工程应用的潜力。事实上，虽然合成组蛋白甲基化已广泛用于基因表达工程，但非组蛋白甲基化工程尚未得到充分探索。在这里，我们报告了最新的发现，强调非组蛋白甲基化对于某些细胞功能至关重要并与疾病有关，并回顾了蛋白质甲基化工程的最新研究成果。

更新日期：2021-02-19

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