The tumor suppressor prostate apoptosis response-4 (Par-4) has recently turned ‘twenty-five’. Beyond its indisputable role as an apoptosis inducer, an increasing and sometimes bewildering, new roles for Par-4 are being reported. These roles include its ability to regulate autophagy, senescence, and metastasis. This growing range of responses to Par-4 is reflected by our increasing understanding of the various mechanisms through which Par-4 can function. In this review, we summarize the existing knowledge on Par-4 tumor suppressive mechanisms, and discuss how the interaction of Par-4 with different regulators influence cell fate. This review also highlights the new secretory pathway that has emerged and the likely discussion on its clinical implications.

肿瘤抑制前列腺细胞凋亡反应 4 (Par-4) 最近已变成“25 岁”。除了作为细胞凋亡诱导剂的无可争议的作用之外，还报道了 Par-4 的新作用越来越多，有时甚至令人困惑。这些作用包括调节自噬、衰老和转移的能力。对 Par-4 的反应范围不断扩大，这反映在我们对 Par-4 发挥作用的各种机制的日益了解。在这篇综述中，我们总结了关于 Par-4 肿瘤抑制机制的现有知识，并讨论了 Par-4 与不同调节剂的相互作用如何影响细胞命运。本综述还强调了出现的新分泌途径及其临床意义的可能讨论。