ABSTRACT

Background: A few studies investigated the relationship between allergy and Meniere disease considering complete allergen panel. We aimed to evaluate the serum immunoreactivity in patients with Meniere’s disease (MD) compared with healthy people according to common indigenous Iranian inhalation and food allergens.

Methods: Thirty-nine patients with MD referred to Rasoul Akram Hospital (Tehran, Iran) were evaluated and compared with a 41 membered control group. A panel of common inhalation and food allergens (using an immunoblotting method), as well as total immunoglobulin E (IgE) level (using the sandwich enzyme-linked immunosorbent assay method), were checked on the patients’ serum.

Results: The mean total IgE level was 193.85 ± 175.43 IU/ml in the patients with MD and 117.61 ± 138.05 IU/ml in the control group, which was significantly higher than the other subjects in the control group (P = .016). There was a significant difference between the two groups regarding inhalation allergens such as; sweet vernal grass, cultivated rye, cultivated oat, Russian thistle, goosefoot, and rough pigweed (P = .01–0.038). Patients with MD reported more reactive to food allergens such as; rye flour, hazelnut, pepper, citrus mix 2, potato, strawberry, and celery allergens. There was a significant relationship between Meniere and serum immunoreactivity to inhalation and food allergens (both P = .001).

Conclusion: Serum total IgE level in patients with MD (in both inhalation and food allergens groups) was higher than the control group, and there was a relationship between MD and immunoreactivity to common indigenous inhalation and food allergens of Iran.

摘要

背景：考虑到完整的过敏原组，一些研究调查了过敏与梅尼埃病之间的关系。我们旨在根据伊朗当地常见的吸入和食物过敏原评估与健康人相比的美尼尔氏病（MD）患者的血清免疫反应性。

方法：评估了Rasoul Akram医院（伊朗德黑兰）的39例MD患者，并将其与41名对照组进行了比较。检查患者血清中的一组常见吸入和食物过敏原（使用免疫印迹方法）以及总免疫球蛋白E（IgE）水平（使用夹心酶联免疫吸附测定方法）。

结果：MD患者的平均总IgE水平为193.85±175.43 IU / ml，对照组为117.61±138.05 IU / ml，明显高于对照组的其他受试者（P = 0.016）。两组之间在吸入性过敏原方面存在显着差异，例如；甜的春草，栽培的黑麦，栽培的燕麦，俄罗斯蓟，鹅掌和粗杂草（P = .01–0.038）。MD患者报告对食物过敏原的反应性更高，例如；黑麦面粉，榛子，胡椒粉，柑橘类混合物2，马铃薯，草莓和芹菜过敏原。梅尼埃病与血清对吸入和食物过敏原的免疫反应性之间存在显着相关性（均P = 0.001）。

结论：MD患者（吸入和食物过敏原组）的血清总IgE水平高于对照组，并且MD与伊朗常见的本地吸入和食物过敏原的免疫反应性之间存在相关性。