Abstract

Introduction

The development of ophthalmic formulations able to deliver hydrophilic and hydrophobic drugs to the inner structures of the eye and restore the preocular tear film has been a leading topic of discussion over the last few years. In this sense, liposomes represent a suitable strategy to achieve these objectives in ocular drug delivery.

Areas covered

Knowledge of the different physiological and anatomical structures of the eye, and specially the ocular surface are critical to better understanding and comprehending the characteristics required for the development of topical ophthalmic liposomal formulations. In this review, several features of liposomes are discussed such as the essential materials used for their fabrication, basic structure and preparation methods, from already established to novel techniques, allowing the control and design of special characteristics. Besides, physicochemical properties, purification processes and important strategies to overcome delivery or encapsulation challenges are also presented.

Expert opinion

Regarding ocular drug delivery of liposomes, there are some features that can be re-designed. Specific biocompatible and biodegradable materials presenting therapeutic properties, such as lipidic compounds or polymers significantly change the way of tackling ophthalmic diseases. Besides, liposomes entail an effective, safe and versatile strategy for the treatment of diseases in the clinical practice.

中文翻译：

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脂质体作为局部眼科药物输送和眼表保护的载体

摘要

介绍

能够将亲水性和疏水性药物递送至眼睛内部结构并恢复眼前泪膜的眼科制剂的开发已成为最近几年讨论的主要话题。从这个意义上讲，脂质体代表了实现眼部药物递送中这些目标的合适策略。

覆盖区域

了解眼睛的不同生理和解剖结构，特别是眼表，对于更好地理解和理解局部眼用脂质体制剂开发所需的特性至关重要。在这篇综述中，讨论了脂质体的几个特征，例如用于脂质体制造的基本材料，基本结构和制备方法，从已经建立的到新颖的技术，都可以控制和设计特殊的特征。此外，还介绍了理化性质，纯化工艺和克服递送或封装挑战的重要策略。

专家意见

关于脂质体的眼部药物输送，有些功能可以重新设计。具有治疗特性的特定生物相容性和可生物降解材料，例如脂质化合物或聚合物，极大地改变了解决眼科疾病的方式。此外，脂质体在临床实践中需要一种有效，安全和通用的疾病治疗策略。