ABSTRACT

Introduction

Polymers have various applications such as binder, film coating agent, stabilizer, drug release modification, and as primary packaging materials. Recently, they have been explored in co-processing technique to improve the functionality of small molecule excipients (SMEs). Co-processing is a concept wherein two or more excipients interact at sub-particle level to provide synergy in functionality and minimize drawbacks of individual excipients.

Area covered

The present review highlights the application of co-processing to improve the functionality of SMEs using polymers; physicochemical and mechanical properties of polymers for co-processing; advantages of co-processed excipients for different applications; functionality enhancement of co-processed excipients; novel concepts/methods for co-processing; mechanistic insights on co-processing and commercial products available in the market.

Expert opinion

Most of the SMEs do not possess optimal multifunctional properties like flow, compressibility, compactibility, and disintegration ability, required to compensate for poorly compactable drugs. Some of these drawbacks can be overcome by co-processing of SMEs with polymers. For example, co-processing of a brittle SME and plastic material (polymer) can provide a synergistic effect and result in the generation of single entity multi-functional excipient. Besides, novel co-processed excipients generated using combinations of SMEs and polymers can also generate intellectual property rights.

中文翻译：

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小分子赋形剂与聚合物的协同处理以改善功能

摘要

介绍

聚合物具有多种用途，例如粘合剂、薄膜包衣剂、稳定剂、药物释放改性以及作为初级包装材料。最近，他们在协同处理技术中进行了探索，以改善小分子赋形剂 (SME) 的功能。协同加工是一种概念，其中两种或多种赋形剂在亚颗粒水平上相互作用，以提供功能协同作用并最大限度地减少单个赋形剂的缺点。

覆盖面积

本综述强调了协同处理的应用，以改善使用聚合物的中小企业的功能；用于协同处理的聚合物的物理化学和机械性能；协同加工赋形剂在不同应用中的优势；协同加工赋形剂的功能增强；协同处理的新概念/方法；对市场上可用的协同处理和商业产品的机械见解。

专家意见

大多数中小型企业不具备最佳的多功能特性，如流动性、可压缩性、可压缩性和崩解能力，而这些特性是弥补可压缩性差的药物所需的。这些缺点中的一些可以通过 SMEs 与聚合物的协同加工来克服。例如，脆性 SME 和塑料材料（聚合物）的协同加工可以提供协同效应并导致生成单一实体多功能赋形剂。此外，使用中小企业和聚合物组合产生的新型协同加工赋形剂也可以产生知识产权。