Citrobacter spp., Enterobacter hormaechei subsp., Klebsiella variicola and Proteae tribe members are rarely isolated Enterobacterales increasingly implicated in nosocomial infections. Herein, we show that these species contain multiple genes encoding resistance to important antibiotics and are widely and globally distributed, being isolated from human, animal, plant, and environmental sources in 67 countries. Certain clones and clades of these species were internationally disseminated, serving as reservoirs and mediums for the global dissemination of antibiotic resistance genes. As they can easily transmit these genes to more pathogenic species, additional molecular surveillance studies should be undertaken to identify and contain these antibiotic-resistant species.

中文翻译：

---

柠檬酸杆菌属、荷马氏肠杆菌、水痘克雷伯菌和变形杆菌克隆的全球进化流行病学和抗性组动力学

柠檬酸杆菌属、荷马氏肠杆菌亚种、水痘克雷伯菌和变形杆菌部落成员很少是孤立的肠杆菌，越来越多地与医院感染有关。在这里，我们表明这些物种包含多个编码对重要抗生素的抗性的基因，并且在全球范围内广泛分布，从 67 个国家的人类、动物、植物和环境来源中分离出来。这些物种的某些克隆和进化枝在国际上传播，作为抗生素抗性基因全球传播的储存库和媒介。由于它们可以很容易地将这些基因传播给更具致病性的物种，因此应该进行额外的分子监测研究来识别和控制这些抗生素抗性物种。