1. A high percentage of marine animals produce bioactive compounds that may play a leading role in the discovery of future compounds and drugs of marine origin. However, commercial fishing and other human activities leading to sea warming and pollution may affect these marine animals, even putting them in danger of extinction.
2. To date, no comprehensive studies have evaluated the conservation status of Mediterranean species with bioactive potential, which is crucial to better understanding of how these species cope with the impacts of human activity.
3. The study reviewed the bioactive potential and vulnerability of 833 fish and macro-invertebrate species inhabiting the marine protected area of Cap de Creus and surrounding areas. The most active taxa found were Porifera (49 out of 59 species; 83.0%) and Tunicata (17 out of 27 species; 63.0%). The most vulnerable species were Chondrichthyes (eight out of nine species) and Porifera (nine out of 12 species), which together account for over 75% of species classified as such.
4. Results emphasize the need to introduce specific management measures that protect vulnerable species with bioactive potential as this is a valuable component of marine ecosystems, as well as a potential source of molecules with pharmacological properties beneficial for human health.
5. Marine protected areas can contribute to preserving marine species of medical interest and achieving their sustainable use in the marine biotechnology industry.

中文翻译：

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地中海海洋保护区中具有生物活性潜力的鱼类和大型无脊椎动物物种的脆弱性

1. 很大比例的海洋动物会产生生物活性化合物，这些化合物可能在未来海洋来源的化合物和药物的发现中发挥主导作用。然而，商业捕鱼和其他导致海洋变暖和污染的人类活动可能会影响这些海洋动物，甚至使它们面临灭绝的危险。
2. 迄今为止，还没有全面的研究评估具有生物活性潜力的地中海物种的保护状况，这对于更好地了解这些物种如何应对人类活动的影响至关重要。
3. 该研究审查了栖息在 Cap de Creus 海洋保护区和周边地区的 833 种鱼类和大型无脊椎动物的生物活性潜力和脆弱性。发现的最活跃的分类群是 Porifera（59 个物种中的 49 个；83.0%）和 Tunicata（27 个物种中的 17 个；63.0%）。最脆弱的物种是软骨鱼类（九个物种中的八个）和 Porifera（十二个物种中的九个），它们总共占被归类为此类的物种的 75% 以上。
4. 结果强调需要采取具体的管理措施来保护具有生物活性潜力的脆弱物种，因为这是海洋生态系统的重要组成部分，也是具有有益于人类健康的药理特性的分子的潜在来源。
5. 海洋保护区有助于保护具有医学意义的海洋物种并实现其在海洋生物技术行业中的可持续利用。