A novel palladium (II) complex with a ferrocene-based ligand (Fc-Ppd-2) was synthesized and thoroughly characterized. Its configuration was confirmed by X-ray single crystal diffraction. In vitro anticancer study showed excellent activity of Fc-Ppd-2 against ACHN, Mcf-7 and its drug-resistant cell line, with potency up to 25-fold better than cisplatin while remaining less toxic in normal cells. Flow cytometry analysis indicated that the complex exerted antiproliferation activity through induction of cell apoptosis.

中文翻译：

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具有二茂铁基配体的新型钯（II）配合物：合成，X射线晶体学和体外抗癌活性研究

合成了新型的具有二茂铁基配体（Fc-Ppd-2）的钯（II）配合物，并对其进行了全面表征。通过X射线单晶衍射确认了其构型。体外抗癌研究显示Fc-Ppd-2对ACHN，Mcf-7及其耐药细胞系具有出色的活性，效力比顺铂高25倍，而对正常细胞的毒性较小。流式细胞仪分析表明该复合物通过诱导细胞凋亡发挥抗增殖活性。