Using of polymer encapsulated beads with antimicrobial agents is a novel and very promising strategy. In this study, a natural polymer; Sodium alginate, was used to encapsulate the very efficient disinfection agent; Virkon S for the first time. Preparation and characterization of beads was done by FTIR, UV/Vis and microscopy. Quantitative releasing of Virkon S from beads was also analyzed. After chemical analyses, microbiological analysis was done by performing time-kill assays to assess time-dependent antimicrobial activity of beads. These assays were performed by simulating contaminated water which contained three types of standard bacterial strains separately; Methicillin Sensitive Staphylococcus aureus (MSSA), Methicillin Resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli). The results showed that more than 50% of Virkon S was released at 90th min and releasing was totally stabilized after 30 h. The time-killing assays indicated that the beads can effectively inhibit the growth of different bacteria including antibiotic resistant strains in water. 100.00 mg weighed beads killed all of the MRSA, MSSA and E. coli cells successfully at 15th, 120th and 180th min of contact time respectively. Our results showed that, Virkon S-alginate beads can be considered as promising disinfecting agents for several applications ranging from remediation of environmental water sources to cleaning of the various liquids in hospital setting.

将聚合物包封的微珠与抗微生物剂一起使用是一种新颖且非常有前途的策略。在这项研究中，天然聚合物；海藻酸钠被用来封装非常有效的消毒剂。第一次使用VirkonS。珠的制备和表征通过FTIR，UV / Vis和显微镜进行。还分析了Virkon S从珠粒中的定量释放。在进行化学分析之后，通过进行时间杀灭测定以评估珠子的时间依赖性抗菌活性来进行微生物分析。通过模拟分别包含三种标准细菌菌株的污水进行这些测定。耐甲氧西林金黄色葡萄球菌（MSSA），耐甲氧西林金黄色葡萄球菌（MRSA）和大肠杆菌（E. coli）。结果表明，第90分钟释放了超过50％的Virkon S，并且在30 h后释放完全稳定。时间杀灭试验表明，珠子可以有效地抑制不同细菌的生长，包括水中的抗生素抗性菌株。分别在接触时间的第15、120和180分钟分别成功称重100.00 mg珠子，杀死所有MRSA，MSSA和大肠杆菌细胞。我们的结果表明，Virkon S-藻酸盐微珠可被视为有前途的消毒剂，适用于从环境水的修复到医院环境中各种液体的多种应用。