Background/Aim: Dual-specificity protein phosphatase 4 (DUSP4) negatively regulates MAPK signaling and is involved in various cellular processes. We herein evaluated the relationship between DUSP4 expression and clinicopathological characteristics in a large series of gastric cancer samples. Materials and Methods: DUSP4 expression was examined by immunohistochemistry in 508 gastric cancer samples. Cases were classified according to the TCGA molecular classification and HER2 amplification. Kaplan-Meier plots were used to predict the relationship between mRNA expression of DUSP4 and survival. Results: Low expression of DUSP4 was significantly correlated with larger tumor size, higher pT category, positive nodal status, higher stage, lymphovascular invasion, perineural invasion, worse overall survival, and worse recurrence-free survival. No correlation was observed between DUSP4 expression and molecular characteristics. Bioinformatics analysis showed that low mRNA expression was associated with a poor prognosis. Conclusion: Low expression of DUSP4 is associated with aggressive phenotypes of gastric cancer and a poor prognosis.

中文翻译：

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DUSP4 低表达与胃癌的侵袭性表型和预后不良有关

背景/目的：双特异性蛋白磷酸酶 4 (DUSP4) 负向调节 MAPK 信号传导并参与各种细胞过程。我们在此评估了大量胃癌样本中 DUSP4 表达与临床病理学特征之间的关系。材料和方法：通过免疫组织化学检测 508 例胃癌样本中 DUSP4 的表达。根据TCGA分子分类和HER2扩增对病例进行分类。Kaplan-Meier图用于预测DUSP4的mRNA表达与存活率之间的关系。结果：DUSP4 的低表达与较大的肿瘤大小、较高的 pT 类别、阳性淋巴结状态、较高的分期、淋巴血管侵犯、神经周围侵犯、较差的总生存期和较差的无复发生存期显着相关。在DUSP4表达和分子特征之间没有观察到相关性。生物信息学分析表明，低 mRNA 表达与预后不良有关。结论：DUSP4低表达与胃癌侵袭性表型和预后不良有关。