Background: The aim of the present work was to evaluate the prognostic significance in patients with T1 breast cancer of tissue expression of the two oncosuppressors phosphatase and tensin homolog (PTEN) and non-metastatic clone 23 (NM23) as detected by immunohistochemistry. Materials and Methods: We prospectively analyzed 62 patients who underwent surgery for a T1 stage breast cancer. Expression of PTEN and NM23 was tested for correlation with clinical characteristics and clinical outcome. Results: Of the 62 patients considered for our study, 16 underwent mastectomy and 46 underwent conservative surgical treatment. The surgery was considered radical (R0) in all cases described. PTEN and NM23 expression was higher in patients with no lymph node metastases and no recurrent cancer at a mean follow-up of 36 months (range=6-48 months). This correlation was more evident when both PTNE and NM23 expression were highly expressed (p<0.0001). Conclusion: Low or lack of PTEN and NM23 immunohistochemical expression in cancer tissue is a risk factor for lymph node involvement and recurrent disease. It may represent a valid prognostic factor in planning therapy in patients who had surgery for T1 breast cancer.

中文翻译：

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肿瘤抑制因子 PTEN 和 NM23 与 T1 期乳腺癌患者临床结果的相关性

背景：本工作的目的是评估免疫组织化学检测到的两种抑癌基因磷酸酶和张力蛋白同源物 (PTEN) 和非转移性克隆 23 (NM23) 的组织表达对 T1 乳腺癌患者的预后意义。材料和方法：我们前瞻性分析了 62 名接受 T1 期乳腺癌手术的患者。测试了 PTEN 和 NM23 的表达与临床特征和临床结果的相关性。结果：在我们研究的 62 名患者中，16 名接受了乳房切除术，46 名接受了保守手术治疗。在所有描述的病例中，手术都被认为是激进的（R0）。在平均随访 36 个月（范围=6-48 个月）时，无淋巴结转移和无复发癌症的患者中 PTEN 和 NM23 表达较高。当 PTNE 和 NM23 表达均高表达时，这种相关性更为明显（p<0.0001）。结论：癌组织中PTEN和NM23免疫组化表达低或缺乏是淋巴结受累和复发的危险因素。它可能代表了对接受 T1 乳腺癌手术的患者计划治疗的有效预后因素。