Background/Aim: Sulfite oxidase (SUOX) is an enzyme present in the mitochondria, which has been demonstrated to be correlated with various malignant tumours. Materials and Methods: We evaluated SUOX expression in tissues of 98 cases of advanced gastric cancer and performed a clinicopathological assessment for metrics. Results: Among 98 cases, 55 cases were classified into the SUOX low expression group, and 43 cases into the SUOX high expression group. There were more pStage IV cases in the low expression group. The median overall survival of the low expression group was shorter than that of the high expression group (p=0.020). In univariate and multivariate analysis, SUOX low expression level (p=0.039) and pStage (p<0.001) were independent prognostic factors. Conclusion: SUOX is an independent prognostic factor. Therefore, SUOX expression could also serve as a useful marker for elucidating the mechanism of gastric cancer proliferation and progression.

中文翻译：

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亚硫酸盐氧化酶是晚期胃癌的新型预后生物标志物

背景/目的：亚硫酸盐氧化酶 (SUOX) 是一种存在于线粒体中的酶，已被证明与各种恶性肿瘤有关。材料和方法：我们评估了 98 例晚期胃癌组织中 SUOX 的表达，并对指标进行了临床病理学评估。结果：98例中，SUOX低表达组55例，SUOX高表达组43例。低表达组有更多的pStage IV病例。低表达组的中位总生存期短于高表达组（p=0.020）。在单变量和多变量分析中，SUOX 低表达水平 (p=0.039) 和 pStage (p<0.001) 是独立的预后因素。结论：SUOX是一个独立的预后因素。所以，