Background/Aim: To elucidate factors associated with secular changes of grip strength (GS) in patients with chronic liver diseases (CLDs) (n=241, 102 males, median age=63 years, 87 liver cirrhosis cases). Materials and Methods: ΔGS (kg/year) was defined as [GS value (second time) – GS value (first time)]/[time interval between the first and second time]. GS loss (GSL) was defined as ΔGS <0 kg/year. Results: The median ΔGS in patients with non-LC, Child-Pugh A (n=70) and Child-Pugh B (n=17) were 0.3, –0.2 and –1.6 kg/year (overall p<0.0001). In the multivariate analysis of factors linked to the GSL for all cases, extracellular water (ECW) to total body water (TBW) ratio was significant (p=0.0007). In the multivariate analysis in male, no significant factor was found, while in female, ECW to TBW ratio was significant (p=0.0024). Conclusion: Liver functional parameters can be closely linked to the GSL especially in female CLD patients.

中文翻译：

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慢性肝病患者握力下降的预测因素

背景/目的：阐明与慢性肝病（CLD）患者（n = 241，102 名男性，中位年龄 = 63 岁，87 例肝硬化）握力 (GS) 长期变化相关的因素。材料和方法：ΔGS（公斤/年）定义为[GS 值（第二次）– GS 值（第一次）]/[第一次和第二次之间的时间间隔]。GS 损失 (GSL) 定义为 ΔGS <0 kg/年。结果：非 LC、Child-Pugh A（n=70）和 Child-Pugh B（n=17）患者的中位 ΔGS 为 0.3、–0.2 和 –1.6 kg/年（总体 p<0.0001）。在所有病例的 GSL 相关因素的多变量分析中，细胞外水 (ECW) 与全身水 (TBW) 的比率显着 (p = 0.0007)。在男性的多变量分析中，未发现显着因素，而在女性中，ECW 与 TBW 的比率显着（p = 0.0024）。结论：