Background To test the nature of the ocular side effects induced by topiramate (TPM) whether dose dependent or idiosyncratic, and to test various predictors that might influence the occurrence of those side effects. Methods Twenty patients treated with TPM were included in this study. Patients underwent ophthalmic assessment before and after 4 weeks of treatment by stable doses of oral TPM. We examined non-cycloplegic refraction (RF) in diopters, best corrected visual acuity (BCVA), intraocular pressure (IOP) in mmHg, and anterior chamber depth (ACD) in mm. Results There were no statistically significant differences between baseline and follow-up assessments in all tested ophthalmological parameters including errors of RF, ACD, IOP, and the BCVA. One case suffered from painful drop of vision in both eyes with elevated IOP and decreased ACD, and evident myopic shift 1 week after treatment with small dose of TPM. There was no significant effect of age, TPM dose, disease, and gender on all tested variables. Conclusion TPM can induce idiosyncratic, but not dose dependent, ocular side effects, namely myopic shifts and angle closure glaucoma. Those side effects were not disease, age, or gender dependent. However, ethnicity might play a role in induction of those side effects.

中文翻译：

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埃及患者托吡酯引起的眼部副作用，特异与剂量依赖性效应，一项前瞻性研究

背景 测试托吡酯 (TPM) 引起的眼部副作用的性质，无论是剂量依赖性还是特异质的，并测试可能影响这些副作用发生的各种预测因素。方法本研究包括接受TPM治疗的20名患者。患者在接受稳定剂量的口服 TPM 治疗前后 4 周接受眼科评估。我们检查了屈光度的非散瞳性屈光度 (RF)、最佳矫正视力 (BCVA)、眼压 (IOP)（毫米汞柱）和前房深度（ACD）（毫米）。结果 在所有测试的眼科参数（包括 RF、ACD、IOP 和 BCVA 的误差）中，基线和后续评估之间没有统计学显着差异。1例双眼视力下降，眼压升高，ACD降低，小剂量TPM治疗1周后出现明显近视移位。年龄、TPM 剂量、疾病和性别对所有测试变量没有显着影响。结论 TPM 可诱发特异但不依赖剂量的眼部副作用，即近视移位和闭角型青光眼。这些副作用与疾病、年龄或性别无关。然而，种族可能在诱发这些副作用方面发挥作用。