Background Prognostic significance of troponin-I (T-I) elevation for poor short-term outcome in thrombolyzed ischemic stroke patients remains uncertain. Objectives To evaluate its role as a predictive biomarker of short-term outcome in thrombolyzed ischemic stroke patients. Methods This study included 72 acute ischemic stroke patients who were treated with intravenous thrombolytic therapy. All patients were subjected to clinical assessment and measurement of serum T-I level on admission. Outcome was assessed 3 months after stroke onset using the National Institute of Health Stroke Scale (NIHSS) and modified Rankin scale. Results Thirteen patients had elevated serum T-I level (group 1) and the remaining 59 were classified as group 2. Group 1 had a higher statistically significant older age, history of diabetes mellitus (DM), previous stroke, atrial fibrillation (AF), and admission NIHSS score, with significant decrease in high-density lipoprotein cholesterol ( P < 0.05). Regarding the outcome of both groups, good outcome was significantly less common among group 1. Also, death was significantly more common among group I. Poor outcome in group 1 were significantly associated with older age, DM, AF, elevated serum T-I level at admission, and higher admission NIHSS score ( P = 0.03, 0.04, 0.02, 0.05, and 0.001 respectively). The predictors of poor outcome in group 1 were elevated serum T-I level at admission, higher admission NIHSS score, and DM ( P = 0.001, 0.02, and 0.05 respectively). Conclusion Elevated serum T-I levels on admission is a reliable prognostic predictor of poor outcome in thrombolyzed ischemic stroke patients. Trial registration ClinicalTrials.gov NCT03925298 (19 April 2019) “retrospectively registered,”

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肌钙蛋白 I 升高可预测缺血性卒中患者溶栓后的结果

背景 肌钙蛋白 I (TI) 升高对溶栓性缺血性卒中患者短期预后不良的预后意义仍不确定。目的 评估其作为溶栓性缺血性卒中患者短期结果预测生物标志物的作用。方法 本研究包括 72 名接受静脉溶栓治疗的急性缺血性卒中患者。所有患者入院时均接受临床评估和血清 TI 水平测量。在卒中发作后 3 个月，使用美国国立卫生研究院卒中量表 (NIHSS) 和改良的 Rankin 量表评估结果。结果 13 名患者血清 TI 水平升高（第 1 组），其余 59 名被归类为第 2 组。第 1 组具有更高的统计学显着年龄、糖尿病 (DM) 病史、既往卒中、房颤（AF）和入院 NIHSS 评分，高密度脂蛋白胆固醇显着降低（ P < 0.05）。关于两组的结果，第 1 组的良好结果显着较少。此外，第 I 组的死亡显着更常见。第 1 组的不良结果与年龄较大、DM、AF、入院时血清 TI 水平升高显着相关和更高的入院 NIHSS 分数（分别为 P = 0.03、0.04、0.02、0.05 和 0.001）。第 1 组预后不良的预测因素是入院时血清 TI 水平升高、入院时 NIHSS 评分较高和 DM（分别为 P = 0.001、0.02 和 0.05）。结论 入院时血清 TI 水平升高是溶栓性缺血性卒中患者预后不良的可靠预测指标。试验注册临床试验。