The ongoing global COVID-19 pandemic is caused by SARS-CoV-2, a novel coronavirus first discovered at the end of 2019. It has led to more than 50 million confirmed cases and more than 1 million deaths across 219 countries as of 11 November 2020, according to WHO statistics. SARS-CoV-2, SARS-CoV, and MERS-CoV are similar. They are highly pathogenic and threaten public health, impair the economy, and inflict long-term impacts on society. No drug or vaccine has been approved as a treatment for these viruses. Efforts to develop antiviral measures have been hampered by the insufficient understanding of how the human body responds to viral infections at the cellular and molecular levels. In this study, journal articles and transcriptomic and proteomic data surveying coronavirus infections were collected. Response genes and proteins were then identified by differential analyses comparing gene/protein levels between infected and control samples. Finally, the H2V database was created to contain the human genes and proteins that respond to SARS-CoV-2, SARS-CoV, and MERS-CoV infection. H2V provides molecular information about the human response to infection. It can be a powerful tool to discover cellular pathways and processes relevant for viral pathogenesis to identify potential drug targets. It is expected to accelerate the process of antiviral agent development and to inform preparations for potential future coronavirus-related emergencies. The database is available at: http://www.zhounan.org/h2v .

中文翻译：

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H2V：响应 SARS-CoV-2、SARS-CoV 和 MERS-CoV 感染的人类基因和蛋白质数据库


正在进行的全球 COVID-19 大流行是由 SARS-CoV-2 引起的，这是一种于 2019 年底首次发现的新型冠状病毒。截至 11 月 11 日，已在 219 个国家/地区导致超过 5000 万例确诊病例和超过 100 万人死亡据世界卫生组织统计，2020年。 SARS-COV-2、SARS-COV 和 MERS-COV 相似。它们具有高致病性，威胁公众健康，损害经济，并对社会造成长期影响。目前还没有药物或疫苗被批准用于治疗这些病毒。由于对人体如何在细胞和分子水平上对病毒感染做出反应的了解不够，开发抗病毒措施的努力受到了阻碍。在这项研究中，收集了调查冠状病毒感染的期刊文章以及转录组和蛋白质组数据。然后通过比较感染样品和对照样品之间的基因/蛋白质水平的差异分析来鉴定反应基因和蛋白质。最后，创建了 H2V 数据库，其中包含对 SARS-CoV-2、SARS-CoV 和 MERS-CoV 感染做出反应的人类基因和蛋白质。 H2V 提供有关人类对感染反应的分子信息。它可以成为发现与病毒发病机制相关的细胞途径和过程以识别潜在药物靶点的强大工具。预计它将加速抗病毒药物的开发进程，并为未来潜在的冠状病毒相关紧急情况的准备工作提供信息。该数据库可在以下网址获取：http://www. Zhounan.org/h2v 。