Magnetic triggers in biomedical applications – prospects for contact free cell sensing and guidance,Journal of Materials Chemistry B

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Magnetic triggers in biomedical applications – prospects for contact free cell sensing and guidance
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2021-1-7 , DOI: 10.1039/d0tb02474k
Ana F. Almeida _{1,

2,

3,

4,

5} , Adriana Vinhas _{1,

2,

3,

4,

5} , Ana I. Gonçalves _{1,

2,

3,

4,

5} , Margarida S. Miranda _{1,

2,

3,

4,

5} , Márcia T. Rodrigues _{1,

2,

3,

4,

5} , Manuela E. Gomes _{1,

2,

3,

4,

5}

Affiliation

In recent years, the inputs from magnetically assisted strategies have been contributing to the development of more sensitive screening methods and precise means of diagnosis to overcome existing and emerging treatment challenges. The features of magnetic materials enabling in vivo traceability, specific targeting and space- and time-controlled delivery of nanomedicines have highlighted the resourcefulness of the magnetic toolbox for biomedical applications and theranostic strategies. The breakthroughs in magnetically assisted technologies for contact-free control of cell and tissue fate opens new perspectives to improve healing and instruct regeneration reaching a wide range of diseases and disorders. In this review, the contribution of magnetic nanoparticles (MNPs) will be explored as sophisticated and versatile nanotriggers, evidencing their unique cues to probe and control cell function. As cells detect and engage external magnetic features, these approaches will be overviewed considering molecular engineering and cell programming perspectives as well as cell and tissue targeting modalities. The therapeutic relevance of MNPs will be also emphasized as key components of nanostructured systems to control the release of nanomedicines and in the context of new therapy technologies.

中文翻译：

生物医学应用中的电磁触发器–无接触细胞感测和指导的前景

近年来，磁辅助策略的投入已为开发更灵敏的筛查方法和精确的诊断手段以克服现有和新出现的治疗挑战做出了贡献。磁性材料的特性可实现体内纳米药物的可追溯性，特定的靶向性以及时空控制的交付方式突出了磁性工具箱在生物医学应用和治疗诊断策略方面的足智多谋。磁辅助技术对细胞和组织命运的无接触控制的突破，为改善愈合和指导再生达到广泛的疾病和障碍开辟了新的前景。在这篇综述中，磁性纳米颗粒（MNP）的贡献将被探索为复杂而通用的纳米触发器，以证明其独特的线索来探测和控制细胞功能。当细胞检测并利用外部磁性特征时，将考虑分子工程和细胞程序设计的观点以及细胞和组织靶向方式，对这些方法进行概述。

更新日期：2021-01-07

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