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Taking Advantage of the Morpheein Behavior of Peroxiredoxin in Bionanotechnology
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2021-01-07 , DOI: 10.1021/acs.bioconjchem.0c00621 Matteo Ardini 1 , Andrea Bellelli 2 , David L Williams 3 , Luana Di Leandro 1 , Francesco Giansanti 1 , Annamaria Cimini 1 , Rodolfo Ippoliti 1 , Francesco Angelucci 1
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2021-01-07 , DOI: 10.1021/acs.bioconjchem.0c00621 Matteo Ardini 1 , Andrea Bellelli 2 , David L Williams 3 , Luana Di Leandro 1 , Francesco Giansanti 1 , Annamaria Cimini 1 , Rodolfo Ippoliti 1 , Francesco Angelucci 1
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Morpheeins are proteins that reversibly assemble into different oligomers, whose architectures are governed by conformational changes of the subunits. This property could be utilized in bionanotechnology where the building of nanometric and new high-ordered structures is required. By capitalizing on the adaptability of morpheeins to create patterned structures and exploiting their inborn affinity toward inorganic and living matter, “bottom-up” creation of nanostructures could be achieved using a single protein building block, which may be useful as such or as scaffolds for more complex materials. Peroxiredoxins represent the paradigm of a morpheein that can be applied to bionanotechnology. This review describes the structural and functional transitions that peroxiredoxins undergo to form high-order oligomers, e.g., rings, tubes, particles, and catenanes, and reports on the chemical and genetic engineering approaches to employ them in the generation of responsive nanostructures and nanodevices. The usefulness of the morpheeins’ behavior is emphasized, supporting their use in future applications.
中文翻译：
在生物纳米技术中利用过氧化物酶的吗啡行为
吗啡蛋白是可逆组装成不同寡聚体的蛋白质，其结构受亚基构象变化的控制。这种特性可用于需要构建纳米和新的高阶结构的生物纳米技术。通过利用吗啡肽的适应性来创建图案结构并利用它们对无机和生物物质的先天亲和力，可以使用单个蛋白质构建块实现“自下而上”的纳米结构创建，这可能是有用的或作为支架用于更复杂的材料。过氧化物酶代表了可应用于生物纳米技术的吗啡的范例。这篇综述描述了过氧还蛋白在形成高阶低聚物（例如环、管、颗粒、和链环烷烃，并报告了将它们用于生成响应性纳米结构和纳米器件的化学和基因工程方法。morpheeins 行为的有用性得到强调，支持它们在未来的应用中使用。
更新日期：2021-01-20
中文翻译：
在生物纳米技术中利用过氧化物酶的吗啡行为
吗啡蛋白是可逆组装成不同寡聚体的蛋白质，其结构受亚基构象变化的控制。这种特性可用于需要构建纳米和新的高阶结构的生物纳米技术。通过利用吗啡肽的适应性来创建图案结构并利用它们对无机和生物物质的先天亲和力，可以使用单个蛋白质构建块实现“自下而上”的纳米结构创建，这可能是有用的或作为支架用于更复杂的材料。过氧化物酶代表了可应用于生物纳米技术的吗啡的范例。这篇综述描述了过氧还蛋白在形成高阶低聚物（例如环、管、颗粒、和链环烷烃，并报告了将它们用于生成响应性纳米结构和纳米器件的化学和基因工程方法。morpheeins 行为的有用性得到强调，支持它们在未来的应用中使用。
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