ABSTRACT

Background: biomarkers can be helpful in identifying patients who may profit by explicit treatments or evaluating the reaction to the treatment of specific disease. Finding unique biomarkers in the process of disease could help clinicians in identifying serious disease in the early stage, so as to improve prognosis. Objective: these investigations, nonetheless, have made constrained progress. Numerous infections are known to cause intense viral encephalitis (VE) in people which can cause a variable level of meningeal just as parenchymal aggravation. Initial clinical manifestations in most encephalitis are nonspecific, resembling a viral-like illness. However, with disease progression, symptoms can become quite severe and fatal, including prominent cranial hypertension, cognitive problems, cerebral hernia and respiratory failure. Forwards: the clinical and research center discoveries in huge numbers of those viral issues are to a great extent comparable and in this way increasingly explicit biomarkers for indicative and prognostic intentions are justified. These biomarkers are progressively significant in the acknowledgment and treatment of the viral central nervous system (CNS) issue. Conclusion: Clinical manifestations have been the indicative approaches for analysis of viral encephalitis. Lots of studies have been endeavored to distinguish progressively objective laboratory-based quantitative CSF biomarkers for VE.

中文翻译：

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从临床患者身上深入了解病毒性脑炎的生物标志物

摘要

背景：生物标志物有助于识别可能通过明确治疗获益的患者或评估对特定疾病治疗的反应。在疾病的发展过程中寻找独特的生物标志物可以帮助临床医生在早期识别严重的疾病，从而改善预后。目标：尽管如此，这些调查取得了有限的进展。已知许多感染会在人体内引起严重的病毒性脑炎 (VE)，这会导致不同程度的脑膜病变，就像实质恶化一样。大多数脑炎的初始临床表现是非特异性的，类似于病毒样疾病。然而，随着疾病的进展，症状会变得非常严重和致命，包括突出的颅高压、认知问题、脑疝和呼吸衰竭。转发：临床和研究中心发现的大量这些病毒问题在很大程度上具有可比性，因此越来越明确的指示性和预后意图的生物标志物是合理的。这些生物标志物在确认和治疗病毒性中枢神经系统 (CNS) 问题方面越来越重要。结论：临床表现已成为分析病毒性脑炎的指示性方法。许多研究已努力区分逐渐客观的基于实验室的定量脑脊液生物标志物。这些生物标志物在确认和治疗病毒性中枢神经系统 (CNS) 问题方面越来越重要。结论：临床表现已成为分析病毒性脑炎的指示性方法。许多研究已努力区分逐渐客观的基于实验室的定量脑脊液生物标志物。这些生物标志物在确认和治疗病毒性中枢神经系统 (CNS) 问题方面越来越重要。结论：临床表现已成为分析病毒性脑炎的指示性方法。许多研究已努力区分逐渐客观的基于实验室的定量脑脊液生物标志物。