Although hepcidin synthesis is stimulated by inflammation and inhibited by Fe deficiency, the strength of their opposing effects on serum hepcidin (SHep) in humans remains unclear. It was recently shown that an inflammatory stimulus in anaemic women did not increase SHep or decrease Fe absorption. The enhancing effect of ascorbic acid on Fe absorption may not be effective during inflammation because of increased SHep. Our study aim was to test whether reducing inflammation in Fe-depleted overweight (OW) women with low-grade inflammation would lower SHep and improve Fe absorption with and without ascorbic acid, compared with normal-weight (NW) women without inflammation. Before and after 14 d of anti-inflammatory treatment (3 × 600 mg ibuprofen daily) in OW and NW women (n 36; 19–46 years of age), we measured SHep and fractional Fe absorption (FIA) (erythrocyte Fe incorporation) from 57Fe- and 58Fe-labelled test meals with and without ascorbic acid. There were significant group effects on IL-6, C-reactive protein, serum ferritin and SHep (for all, P < 0·05). There was a significant treatment effect on SHep (P < 0·05): in OW women, treatment decreased IL-6 by approximately 30 % and SHep by approximately 45 %. However, there were no significant treatment or group effects on FIA. Body Fe stores (BIS) were a significant positive predictor of SHep before and after treatment (P < 0·001), but IL-6 was not. Reducing chronic inflammation in OW women halved SHep but did not affect Fe absorption with or without ascorbic acid, and the main predictor of Fe absorption was BIS.

中文翻译：

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在补充和不补充抗坏血酸的情况下，减轻超重女性慢性炎症对血清铁调素和铁吸收的影响

尽管铁调素的合成受到炎症的刺激和铁缺乏的抑制，但它们对人体血清铁调素 (SHep) 的相反作用的强度仍不清楚。最近表明，贫血女性的炎症刺激不会增加 SHep 或减少 Fe 吸收。由于 SHep 增加，抗坏血酸对 Fe 吸收的增强作用在炎症期间可能无效。我们的研究目的是测试与没有炎症的正常体重 (NW) 女性相比，在使用和不使用抗坏血酸的情况下，减少缺铁超重 (OW) 女性的炎症是否会降低 SHep 并改善 Fe 吸收。OW 和 NW 女性接受 14 天抗炎治疗（每天 3 × 600 mg 布洛芬）前后（n36; 19-46 岁），我们从57铁和58含和不含抗坏血酸的铁标记试验餐。对 IL-6、C 反应蛋白、血清铁蛋白和 SHep 有显着的组效应（对所有人来说，磷< 0·05)。对SHep有显着的治疗效果（磷< 0·05)：在 OW 女性中，治疗使 IL-6 降低了大约 30%，SHep 降低了大约 45%。然而，对 FIA 没有显着的治疗或组效应。体铁储备 (BIS) 是治疗前后 SHep 的显着阳性预测因子。磷< 0·001)，但 IL-6 不是。减少 OW 女性的慢性炎症可使 SHep 减半，但在有或没有抗坏血酸的情况下不影响铁的吸收，铁吸收的主要预测因子是 BIS。