Mild cognitive impairment (MCI) (amnestic or non-amnestic) has different clinical and neuropsychological characteristics, and its evolution is heterogeneous. Cardiovascular risk factors (CVRF), such as hypertension, diabetes, or dyslipidemia, and the presence of the Apolipoprotein E ε4 (ApoE ε4) polymorphism have been associated with an increased risk of developing Alzheimer’s disease (AD) and other dementias but the relationship is inconsistent worldwide. We aimed to establish the association between the ApoE ε4 carrier status and CVRF on MCI subtypes (amnestic and non-amnestic) in Mexican older adults. Cross-sectional study including 137 older adults (n = 63 with normal cognition (NC), n = 24 with amnesic, and n = 50 with non-amnesic MCI). Multinomial logistic regression models were performed in order to determine the association between ApoE ε4 polymorphism carrier and CVRF on amnestic and non-amnestic-MCI. ApoE ε4 carrier status was present in 28.8% participants. The models showed that ApoE ε4 carrier status was not associated neither aMCI nor naMCI condition. The interaction term ApoE ε4 × CVRF was not statistically significant for both types of MCI. However, CVRF were associated with both types of MCI and the association remained statistically significant after adjustment by sex, age, and education level. The carrier status of the ApoE genotype does not contribute to this risk.

中文翻译：

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ApoEε4携带者状况与墨西哥老年人轻度认知障碍的心血管危险因素之间的关联

轻度认知障碍（MCI）（遗忘或非遗忘）具有不同的临床和神经心理学特征，其演变是异质的。心血管危险因素（CVRF），例如高血压，糖尿病或血脂异常，以及载脂蛋白Eε4（ApoEε4）多态性的存在与患阿尔茨海默氏病（AD）和其他痴呆症的风险增加相关，但这种关系是全球范围内不一致。我们旨在建立墨西哥老年人中MCI亚型（遗忘和非遗忘）的ApoEε4携带者状态与CVRF之间的关联。横断面研究，包括137位老年人（n = 63，具有正常认知（NC），n = 24，有记忆删除，n= 50（使用非健忘MCI）。为了确定ApoEε4多态性载体与记忆删除和非记忆删除MCI上的CVRF之间的关联，执行了多项logistic回归模型。ApoEε4携带者的状态为28.8％。模型显示，ApoEε4携带者的状态与aMCI或naMCI状况均无关。对于两种类型的MCI，相互作用项ApoEε4×CVRF均无统计学意义。但是，CVRF与两种类型的MCI相关，并且在按性别，年龄和教育水平进行调整后，该关联仍具有统计学意义。ApoE基因型的携带者状况不会导致这种风险。