To control the HIV epidemic at the population level, a 90–90–90 target has been proposed for sub-Saharan Africa, whereby 90 percent of people living with HIV (PLH) should know their HIV status, 90 percent of those diagnosed should be receiving antiretroviral therapy (ART), and 90 percent of those on ART should achieve viral suppression (VS). VS occurs when ART reduces the viral load of PLH to an undetectable level with minimal risk of new infections. We present a two-pronged interdisciplinary analysis, combining geospatial and HIV care continuum techniques, to guide treatment interventions toward achieving the 90–90–90 target in Uganda. We conducted spatiotemporal analysis of VS and constructed HIV care continuums for districts using publicly available data from a centralized laboratory of the Ministry of Health, Uganda. Spatial patterns of VS revealed a distinct east–west pattern of low rates and a north–south pattern of high rates with statistically significant clusters of districts with high and low rates in southwestern and eastern Uganda, respectively. VS rates, calculated in a sequential care continuum framework, revealed local variability as well as a significant gap from the 90–90–90 target by districts. Such evident local variability of VS might indicate the importance of regionally targeted interventions for bringing the HIV epidemic to an end.

为了在人群水平上控制艾滋病毒的流行，已为撒哈拉以南非洲提出了90-90-90的目标，即90％的艾滋病毒感染者（PLH）应了解其艾滋病毒状况，90％的诊断者应了解接受抗逆转录病毒疗法（ART），接受抗逆转录病毒疗法（ART）的患者中有90％应当达到病毒抑制（VS）。当ART将PLH的病毒载量降至无法检测的水平且新感染的风险降至最低时，就会发生VS。我们提出了两方面的跨学科分析，结合了地理空间和HIV护理连续技术，以指导治疗干预措施实现乌干达90-90-90目标。我们使用来自乌干达卫生部中央实验室的公开数据，对VS进行了时空分析，并为各地区构建了HIV护理连续体。VS的空间格局揭示了独特的东西向低利率格局和南北向高利率格局，分别在乌干达西南部和东部具有统计学意义的高率和低率地区集群。在连续护理连续性框架中计算的VS率显示出局部差异以及与各地区90-90-90目标之间的显着差距。VS的这种明显的局部变异性可能表明，针对性地采取区域干预措施对于结束艾滋病毒流行至关重要。揭示了局部差异以及各地区与90-90-90目标之间的显着差距。VS的这种明显的局部变异性可能表明，针对性地采取区域干预措施对于结束艾滋病毒流行至关重要。揭示了局部差异以及各地区与90-90-90目标之间的显着差距。VS的这种明显的局部变异性可能表明，针对性地采取区域干预措施对于结束艾滋病毒流行至关重要。