Bacterial type VII secretion: An important player in host‐microbe and microbe‐microbe interactions,Molecular Microbiology

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Bacterial type VII secretion: An important player in host‐microbe and microbe‐microbe interactions
Molecular Microbiology ( IF 2.6 ) Pub Date : 2021-01-07 , DOI: 10.1111/mmi.14680
Hiu-Ki R Tran _{1,

2} , Dirk W Grebenc _{1,

2} , Timothy A Klein _{1,

2} , John C Whitney _{1,

2,

3}

Affiliation

Type VII secretion systems (T7SSs) are poorly understood protein export apparatuses found in mycobacteria and many species of Gram‐positive bacteria. To date, this pathway has predominantly been studied in Mycobacterium tuberculosis, where it has been shown to play an essential role in virulence; however, much less studied is an evolutionarily divergent subfamily of T7SSs referred to as the T7SSb. The T7SSb is found in the major Gram‐positive phylum Firmicutes where it was recently shown to target both eukaryotic and prokaryotic cells, suggesting a dual role for this pathway in host‐microbe and microbe‐microbe interactions. In this review, we compare the current understanding of the molecular architectures and substrate repertoires of the well‐studied mycobacterial T7SSa systems to that of recently characterized T7SSb pathways and highlight how these differences may explain the observed biological functions of this understudied protein export machine.

中文翻译：

VII型细菌分泌：宿主-微生物和微生物-微生物相互作用的重要参与者

VII 型分泌系统 (T7SSs) 是在分枝杆菌和许多革兰氏阳性菌中发现的蛋白质输出装置，但知之甚少。迄今为止，该途径主要在结核分枝杆菌中进行了研究，它已被证明在毒力方面发挥着重要作用；然而，较少研究的是 T7SSs 的进化发散亚科，称为 T7SSb。T7SSb 存在于主要的革兰氏阳性菌门厚壁菌门中，最近显示它靶向真核细胞和原核细胞，表明该途径在宿主-微生物和微生物-微生物相互作用中具有双重作用。在这篇综述中，我们将目前对分枝杆菌 T7SSa 系统的分子结构和底物库的理解与最近表征的 T7SSb 通路进行比较，并强调这些差异如何解释这种未充分研究的蛋白质输出机器观察到的生物学功能。

更新日期：2021-01-07

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