Pencil beam scanning (PBS) for moving targets is known to be impacted by interplay effects. Four‐dimensional computed tomography (4DCT)‐based motion evaluation is crucial for understanding interplay and developing mitigation strategies. Availability of high‐quality 4DCTs with variable breathing traces is limited. Purpose of this work is the development of a framework for interplay analysis using 4D‐XCAT phantoms in conjunction with time‐resolved irradiation patterns in a commercial treatment planning system (TPS). Four‐dimensional dynamically accumulated dose distributions (4DDDs) are simulated in an in‐silico study for a PBS liver treatment.

中文翻译：

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技术说明：在RayStation治疗计划系统中研究使用4D XCAT幻影进行的铅笔束扫描质子治疗中的相互作用效应

众所周知，移动目标的笔形束扫描（PBS）会受到相互作用的影响。基于四维计算机断层扫描（4DCT）的运动评估对于理解相互作用和制定缓解策略至关重要。具有可变呼吸轨迹的高质量4DCT的可用性受到限制。这项工作的目的是开发一种在商业治疗计划系统（TPS）中使用4D-XCAT幻像与时间分辨的照射模式进行相互作用分析的框架。在一项针对PBS肝治疗的计算机研究中模拟了四维动态累积剂量分布（4DDDs）。