Purification, Characterization, and Antiproliferative Activity of a Single‐Chain Lectin from Vicia palaestina (Fabaceae) Seeds,Chemistry & Biodiversity

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Purification, Characterization, and Antiproliferative Activity of a Single‐Chain Lectin from Vicia palaestina (Fabaceae) Seeds
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2021-01-07 , DOI: 10.1002/cbdv.202000827
Youssef Elamine ₁ , Verenice Torres-Salas ₂ , Alima Messai ₁ , Julio Girón-Calle ₁ , Manuel Alaiz ₁ , Javier Vioque ₁

Affiliation

Vicia palaestina Boiss. is an annual herb that grows in dry areas of eastern Mediterranean countries. It belongs to section Cracca subgenus Vicilla, which is characterized by having a high content in the non-protein amino acid canavanine. The seeds from some of these vetches are also rich in lectins. The purification and characterization of a single-chain lectin from the seeds of V. palaestina is described here. This lectin was the most abundant protein in albumin extracts. It has affinity for the glycoconjugate N-acetylgalactosamine and inhibits proliferation of the cancerous Caco-2 and THP-1 cell lines. In addition to their high nutritional value, the seeds from V. palaestina represent a source of lectins with health promoting and pharmacological potential because of their antiproliferative activity.

中文翻译：

来自 Vicia palaestina (Fabaceae) 种子的单链凝集素的纯化、表征和抗增殖活性

Vicia palaestina Boiss。是一种一年生草本植物，生长在地中海东部国家的干旱地区。属于Cracca亚属Vicilla，其特点是非蛋白氨基酸刀豆氨酸含量高。其中一些野豌豆的种子也富含凝集素。这里描述了从 V. palaestina 种子中纯化和表征单链凝集素。这种凝集素是白蛋白提取物中含量最丰富的蛋白质。它对糖缀合物 N-乙酰半乳糖胺具有亲和力，并抑制癌性 Caco-2 和 THP-1 细胞系的增殖。除了它们的高营养价值外，来自 V. palaestina 的种子代表了凝集素的来源，因为它们具有抗增殖活性，因此具有促进健康和药理学的潜力。

更新日期：2021-01-07

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