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DTBP-promoted decarbonylative alkylation of quinoxaline-2(1H)-ones with aldehydes
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2021-01-07 , DOI: 10.1016/j.tetlet.2020.152720
Bingqing Wang , Hua Yao , Xiaoyang Zhong , Zhaohua Yan , Sen Lin

An efficient DTBP-promoted direct alkylation of quinoxaline-2(1H)-ones with aldehydes has been developed under metal-free conditions. The reaction undergoes sequential decarbonylation and radical addition using aliphatic aldehyde as a cheap and abundant alkyl radical source. A convenient and efficient approach for the synthesis of various 3-alkylquinoxaline-2(1H)-ones was provided.



中文翻译:

DTBP促进喹喔啉-2(1 H)-酮与醛的脱羰烷基化

在无金属条件下开发了一种有效的DTBP促进的喹喔啉-2(1 H)-酮与醛的直接烷基化。使用脂肪族醛作为廉价且丰富的烷基自由基源,使反应进行顺序的脱羰基和自由基加成。提供了一种方便有效的合成各种3-烷基喹喔啉-2(1 H)-的方法。

更新日期:2021-01-21
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