Allergic diseases such as asthma and rhinitis are common health problems that affect hundreds of millions of people in the world. T helper 2 cytokines participate in the immune responses in these diseases. Vitamin E and selenium (Se) are supplementary factors which have immunomodulatory and antioxidant effects. The present study investigated the effects of vit E + Se administration on allergic symptoms in mice models of asthma and rhinitis. Mice were treated with vit E and Se, and the levels of IL-4, IL-5, IL-13, IL-25, IL-33, total IgE, and histamine were measured. Lung histopathology was also analyzed.

Our results indicated that vit E could attenuate allergic rhinitis and asthma symptoms; nevertheless, treatment with Se alone was not effective in controlling allergic symptoms. We noticed reduced airway inflammation and constriction and mucus secretion in the mice, especially when vit E was used in combination with Se.

Our result suggested that vit E, especially in combination with Se, could control allergic mediators and symptoms in rhinitis and asthma and reduce pulmonary inflammation and airway mucus secretion, helping to open obstructed bronchi.

哮喘和鼻炎等过敏性疾病是影响全球数亿人的常见健康问题。T 辅助 2 细胞因子参与这些疾病的免疫反应。维生素 E 和硒 (Se) 是具有免疫调节和抗氧化作用的补充因子。本研究调查了 vit E + Se 给药对哮喘和鼻炎小鼠模型过敏症状的影响。用vit E和Se处理小鼠，并测量IL-4、IL-5、IL-13、IL-25、IL-33、总IgE和组胺的水平。还分析了肺组织病理学。

我们的研究结果表明，维生素 E 可以减轻过敏性鼻炎和哮喘症状；然而，单独用硒治疗不能有效控制过敏症状。我们注意到小鼠气道炎症、收缩和粘液分泌减少，尤其是当维生素 E 与硒联合使用时。

我们的结果表明，维生素 E，尤其是与硒结合，可以控制鼻炎和哮喘的过敏介质和症状，减少肺部炎症和气道粘液分泌，有助于打开阻塞的支气管。