In this study, we assessed circulating immune cells and plasma cytokine levels in 15 pediatric patients with drug-resistant epilepsy (DRE). DRE patients had a significantly higher percentage of CD14+ monocytes positive for IL-1β, IL-1 receptor antagonist, IL-6, and TNF-α than controls. Significantly higher intracellular levels of IFN-γ in CD4+ T cells and NK cells were also found in DRE patients. The level of IL-1β+ CD14+ monocytes correlated with seizure frequency, and intracellular levels of IFN-γ in NKT-like cells were negatively correlated with the duration of epilepsy. Peripheral immune cells might be involved in the pathogenesis of DRE.

中文翻译：

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外周血单核细胞中的白细胞介素 1β 与儿童耐药性癫痫发作频率有关

在这项研究中，我们评估了 15 名患有耐药性癫痫 (DRE) 的儿科患者的循环免疫细胞和血浆细胞因子水平。与对照组相比，DRE 患者的 IL-1β、IL-1 受体拮抗剂、IL-6 和 TNF-α 阳性 CD14+ 单核细胞的百分比显着更高。在 DRE 患者中也发现 CD4+ T 细胞和 NK 细胞中 IFN-γ 的细胞内水平显着更高。IL-1β+CD14+单核细胞水平与癫痫发作频率相关，NKT样细胞内IFN-γ水平与癫痫持续时间呈负相关。外周免疫细胞可能参与了 DRE 的发病机制。